Surface engineering of electrospun polyethylene terephthalate (PET) nanofibers towards development of a new material for blood vessel engineering.
TL;DR: The gelatin grafting method can obviously improve the spreading and proliferation of the ECs on the PET NFM, and moreover, can preserve the EC's phenotype.
About: This article is published in Biomaterials.The article was published on 2005-05-01. It has received 542 citations till now. The article focuses on the topics: Surface modification & Polyethylene terephthalate.
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TL;DR: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers, applicable to virtually every soluble or fusible polymer.
Abstract: Electrospinning is a highly versatile method to process solutions or melts, mainly of polymers, into continuous fibers with diameters ranging from a few micrometers to a few nanometers. This technique is applicable to virtually every soluble or fusible polymer. The polymers can be chemically modified and can also be tailored with additives ranging from simple carbon-black particles to complex species such as enzymes, viruses, and bacteria. Electrospinning appears to be straightforward, but is a rather intricate process that depends on a multitude of molecular, process, and technical parameters. The method provides access to entirely new materials, which may have complex chemical structures. Electrospinning is not only a focus of intense academic investigation; the technique is already being applied in many technological areas.
3,833 citations
TL;DR: Surfaces of electrospun polymeric nanofibers were chemically functionalized for achieving sustained delivery through physical adsorption of diverse bioactive molecules for controlled drug delivery and tissue engineering.
958 citations
TL;DR: The materials, techniques and post modification methods to functionalize electrospun nanofibrous scaffolds suitable for biomedical applications are reviewed.
948 citations
Cites background or methods from "Surface engineering of electrospun ..."
...For examples, nanofibrous scaffolds have been demonstrated as suitable substrates for tissue engineering [24–27], immobilized enzymes and catalyst [33–36], wound dressing [37,38] and artificial blood vessels [39,40]....
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...For example, the grafting of gelatin onto the surface of a polyethylene terephthalate (PET) scaffold after electrospinning could increase the biocompatibility and make the scaffold more suitable for cell adhesion and proliferation [40]....
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...Moreover, the modified scaffold preserved the EC’s phenotype [40]....
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...[40] grafted gelatin onto the electrospun poly(ethylene terephthalate) (PET) nanofibrous scaffolds by using a chemical scheme to overcome the chemical and biological inertness of the PET surface....
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TL;DR: In this article, the authors considered the latest achievements in micro-and nano-thin-film production, including self-assembled nanostructures, in solid nano-particle generation, and in the formation of micro- and nanocapsules.
865 citations
TL;DR: The currently available techniques for nanofiber synthesis are summarized and the use of nanofibers in tissue engineering and drug delivery applications is discussed.
Abstract: Developing scaffolds that mimic the architecture of tissue at the nanoscale is one of the major challenges in the field of tissue engineering. The development of nanofibers has greatly enhanced the scope for fabricating scaffolds that can potentially meet this challenge. Currently, there are three techniques available for the synthesis of nanofibers: electrospinning, self-assembly, and phase separation. Of these techniques, electrospinning is the most widely studied technique and has also demonstrated the most promising results in terms of tissue engineering applications. The availability of a wide range of natural and synthetic biomaterials has broadened the scope for development of nanofibrous scaffolds, especially using the electrospinning technique. The three dimensional synthetic biodegradable scaffolds designed using nanofibers serve as an excellent framework for cell adhesion, proliferation, and differentiation. Therefore, nanofibers, irrespective of their method of synthesis, have been used as scaffolds for musculoskeletal tissue engineering (including bone, cartilage, ligament, and skeletal muscle), skin tissue engineering, vascular tissue engineering, neural tissue engineering, and as carriers for the controlled delivery of drugs, proteins, and DNA. This review summarizes the currently available techniques for nanofiber synthesis and discusses the use of nanofibers in tissue engineering and drug delivery applications.
802 citations
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TL;DR: In this article, a comprehensive review is presented on the researches and developments related to electrospun polymer nanofibers including processing, structure and property characterization, applications, and modeling and simulations.
6,987 citations
TL;DR: Microporous, non-woven poly( epsilon -caprolactone) (PCL) scaffolds made by electrostatic fiber spinning were cultured, expanded and seeded on electrospun PCL scaffolds and suggested as a potential candidate scaffold for bone tissue engineering.
1,939 citations
Book•
01 Jan 1970
TL;DR: In this paper, the colloidal state and structural characteristics of colloidal systems are classified into three categories: colloidal-micelle formation spreading, solid-gas-interfaces, and solid-liquid interfaces.
Abstract: CONTENTS INCLUDE: Preface: 1. The colloidal state: Introduction Classification and colloidal systems Structural characteristics Preparation and purification of colloidal systems: 2. Kinetic properties: The motion of particles in liquid media Brownian motion and translational diffusion The ultracentrifuge Osmotic pressure Rotary Brownian motion: 3. Optical properties: Optical and electron microscopy Light scattering: 4. Liquid-gas and liquid-liquid interfaces Surface and interfacial tensions Adsorption and orientation at interfaces Association colloids-micelle formation spreading Monomolecular films: 5. The solid-gas interface: Adsorption of gases and vapours on solids Composition and structure of solid surfaces: 6. The solid-liquid interface Contact angles and wetting Ore flotation Detergency Adsorption from solution: 7. Charged interfaces: The electric double layer Electrokinetic phenomena Electrokinetic theory: 8. Colloid stability: Lyophobic sols Systems containing lyophilic material Stability control: 9. Rheology: Introduction Viscosity Non-Newtonian flow Viscoelasticity: 10. Emulsions and foams: Oil-in-water and water-in-oil emulsions Foams: Problems Answers References Index.
1,723 citations
TL;DR: The fabrication of synthetic micro- and nano-structured surfaces and the effects of such textured surfaces on cell behavior are reviewed and the hypothesis that the topography of the basement membrane plays an important role in regulating cellular behavior is proposed.
1,450 citations
TL;DR: The results strongly suggest that this synthetic aligned matrix combines with the advantages of synthetic biodegradable polymers, nanometer-scale dimension mimicking the natural ECM and a defined architecture replicating the in vivo-like vascular structure, may represent an ideal tissue engineering scaffold, especially for blood vessel engineering.
1,190 citations