Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy.
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4,074 citations
Cites background from "Survival signalling by Akt and eIF4..."
...Therefore, Wendel et al. (2004) postulated that a downstream target of mTOR mediates anti-apoptotic drug resistance, and they could restore drug resistance by expression of eIF4E....
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...Recent evidence supports the notion that the tumorigenic effects of upstream components of mTOR are mediated by its downstream effectors (Wendel et al. 2004)....
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3,735 citations
3,641 citations
Cites background from "Survival signalling by Akt and eIF4..."
...Indeed, eIF4E promoted cell survival in in vivo mouse models of lymphoma by upregulating the translation of the anti-apoptotic protein myeloid leukaemia cell differentiation 1 (MCL1...
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1,998 citations
1,937 citations
Cites background from "Survival signalling by Akt and eIF4..."
...However, they found that overexpression of eIF4E (the binding partner of the mTORC1-regulated protein 4EBP1) avoided the rapamycin inhibition of growt...
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References
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