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Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown (ペリサイト消失に伴う遷延した炎症による不可逆的な血液網膜関門の破綻)
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The article was published on 2017-07-28 and is currently open access. It has received 6 citations till now.read more
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Journal ArticleDOI
Retinal vasculature development in health and disease.
TL;DR: Recent advances in the understanding of the molecular and cellular mechanisms that govern the interactions between neurons, glial and vascular cells in the developing retina are discussed, including a review of mechanisms that shape the retinal vasculature.
Posted ContentDOI
Pericytes regulate vascular immune homeostasis in the CNS
Orsolya Török,Bettina Schreiner,Hsing-Chuan Tsai,Sebastian G. Utz,Johanna Schaffenrath,Sina Nassiri,Mauro Delorenzi,Adriano Aguzzi,May H. Han,Melanie Greter,Burkhard Becher,Annika Keller +11 more
TL;DR: It is shown that pericytes indirectly restrict immune cell transmigration into the CNS under homeostatic conditions and during autoimmune-driven neuroinflammation by inducing immune quiescence of brain endothelial cells.
Journal ArticleDOI
Pericytes, inflammation, and diabetic retinopathy
TL;DR: The microvascular features of DR are described, and how pericyte depletion and low-grade chronic inflammation contribute to the pathogenesis of this common ophthalmic disorder.
Journal ArticleDOI
THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES: A Review.
Jeffrey S. Heier,Rishi P Singh,Charles C. Wykoff,Karl G. Csaky,Timothy Y Y Lai,Anat Loewenstein,Patricio G. Schlottmann,Liliana P. Paris,Peter D. Westenskow,Carlos Quezada-Ruiz +9 more
TL;DR: Initial clinical evidence suggests a potential benefit of targeting the angiopoietin/Tie pathway and vascular endothelial growth factor (VEGF)-A over anti-VEGF-A monotherapy alone, in part due to the synergistic nature of the pathways.
Journal ArticleDOI
Somatostatin protects human retinal pericytes from inflammation mediated by microglia
Aurora Mazzeo,Ana I. Arroba,Ana I. Arroba,Elena Beltramo,Ángela M. Valverde,Ángela M. Valverde,Massimo Porta +6 more
TL;DR: In conclusion, SST is able to modulate apoptosis/survival pathways in HRP during microglia‐mediated inflammation, evidencing a possible defensive role ofmicroglia in the early phases of DR.
References
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Journal ArticleDOI
Retinal vasculature development in health and disease.
TL;DR: Recent advances in the understanding of the molecular and cellular mechanisms that govern the interactions between neurons, glial and vascular cells in the developing retina are discussed, including a review of mechanisms that shape the retinal vasculature.
Posted ContentDOI
Pericytes regulate vascular immune homeostasis in the CNS
Orsolya Török,Bettina Schreiner,Hsing-Chuan Tsai,Sebastian G. Utz,Johanna Schaffenrath,Sina Nassiri,Mauro Delorenzi,Adriano Aguzzi,May H. Han,Melanie Greter,Burkhard Becher,Annika Keller +11 more
TL;DR: It is shown that pericytes indirectly restrict immune cell transmigration into the CNS under homeostatic conditions and during autoimmune-driven neuroinflammation by inducing immune quiescence of brain endothelial cells.
Journal ArticleDOI
Pericytes, inflammation, and diabetic retinopathy
TL;DR: The microvascular features of DR are described, and how pericyte depletion and low-grade chronic inflammation contribute to the pathogenesis of this common ophthalmic disorder.
Journal ArticleDOI
THE ANGIOPOIETIN/TIE PATHWAY IN RETINAL VASCULAR DISEASES: A Review.
Jeffrey S. Heier,Rishi P Singh,Charles C. Wykoff,Karl G. Csaky,Timothy Y Y Lai,Anat Loewenstein,Patricio G. Schlottmann,Liliana P. Paris,Peter D. Westenskow,Carlos Quezada-Ruiz +9 more
TL;DR: Initial clinical evidence suggests a potential benefit of targeting the angiopoietin/Tie pathway and vascular endothelial growth factor (VEGF)-A over anti-VEGF-A monotherapy alone, in part due to the synergistic nature of the pathways.
Journal ArticleDOI
Somatostatin protects human retinal pericytes from inflammation mediated by microglia
Aurora Mazzeo,Ana I. Arroba,Ana I. Arroba,Elena Beltramo,Ángela M. Valverde,Ángela M. Valverde,Massimo Porta +6 more
TL;DR: In conclusion, SST is able to modulate apoptosis/survival pathways in HRP during microglia‐mediated inflammation, evidencing a possible defensive role ofmicroglia in the early phases of DR.