Sympathetic Nervous System and Hypertension
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...ute to generalized sympathoinhibition and BP reduction after RDN.(70,71) However, reductions in BP after RDN do not seem...
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...various forms of experimental hypertension, including renovascular hypertension.(70) However, the role of renal afferents in hypertension has been controversial....
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...30 mm Hg systolic BP and 10 to 12 mm Hg diastolic BP for ≤24 months.(70,71) When 24-hour ambulatory BP was measured...
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...Early investigators, including Harry Goldblatt74 who first developed reproducible models of renovascular hypertension, found no evidence that renal or splanchnic nerves are necessary for development or maintenance of renovascular hypertension.75 The concept that renal afferents contribute to the BP lowering effects of RDN initially derived from a report that wholebody norepinephrine spillover and MSNA were reduced 1 year after RDN in a single patient.76 Further support for this concept came from the observation that in obese patients with resistant hypertension, radiofrequency RDN decreased MSNA (by only 12% to 14%), as well as BP for ≤1 year.71,77 These findings were interpreted as evidence that interrupting afferent renal nerve pathways to the brain may contribute to generalized sympathoinhibition and BP reduction after RDN.70,71 However, reductions in BP after RDN do not seem to be correlated with reductions in MSNA and some investigators have failed to observe long-term reductions in MSNA after RDN.78 Thus, it is still uncertain whether RDN causes significant decreases in SNA to other organs besides the kidneys....
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