Journal ArticleDOI
Synapomorphic features of hepatic and pulmonary vasculatures include comparable purinergic signaling responses in host defense and modulation of inflammation
Dusan Hanidziar,Simon C. Robson +1 more
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Hepatosplanchnic and pulmonary vasculatures constitute synapomorphic, highly comparable networks integrated with the external environment as discussed by the authors, given functionality related to obligatory requirements of the human body.Abstract:
Hepatosplanchnic and pulmonary vasculatures constitute synapomorphic, highly comparable networks integrated with the external environment. Given functionality related to obligatory requirements of ...read more
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Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response.
TL;DR: MaR1 significantly inhibited an excessive inflammatory response and proinflammatory markers during LPS/D-GalN-induced acute liver injury (ALI) caused by sepsis.
Journal ArticleDOI
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response
TL;DR: MaR1 significantly inhibited an excessive inflammatory response and proinflammatory markers during LPS/D-GalN-induced acute liver injury (ALI) caused by sepsis as discussed by the authors .
Journal ArticleDOI
Airway delivery of Streptococcus salivarius is sufficient to induce experimental pulmonary hypertension in rats
Chenting Zhang,Ting Zhang,Yue Xing,Wenju Lu,Jiyuan Chen,Xiaoyun Luo,Xuefen Wu,Shiyun Liu,Lishi Chen,Zizhou Zhang,Dansha Zhou,Ziying Lin,Yuqin Chen,Mingmei Xiong,Jason X.-J. Yuan,Kai-Chien Yang,Jian Wang +16 more
TL;DR: The causal relationship between altered host microbiome composition, especially the respiratory tract microbiome, and the occurrence of pulmonary hypertension (PH) has not yet been studied as discussed by the authors , but an increased abundance of airway streptococci is seen in patients with PH compared with healthy individuals.
References
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Journal ArticleDOI
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer,Clifford S. Deutschman,Christopher W. Seymour,Manu Shankar-Hari,Djillali Annane,Michael Bauer,Rinaldo Bellomo,Gordon R. Bernard,Jean-Daniel Chiche,Craig M. Coopersmith,Richard S. Hotchkiss,Mitchell M. Levy,John C. Marshall,Greg S. Martin,Steven M. Opal,Gordon D. Rubenfeld,Gordon D. Rubenfeld,Tom van der Poll,Jean Louis Vincent,Derek C. Angus +19 more
TL;DR: The task force concluded the term severe sepsis was redundant and updated definitions and clinical criteria should replace previous definitions, offer greater consistency for epidemiologic studies and clinical trials, and facilitate earlier recognition and more timely management of patients with sepsi or at risk of developing sepsic shock.
Journal ArticleDOI
Acute respiratory distress syndrome: the Berlin Definition.
Ards Definition Task Force,V. Marco Ranieri,Gordon D. Rubenfeld,B. Taylor Thompson,Niall D. Ferguson,Ellen Caldwell,Eddy Fan,Luigi Camporota,Luigi Camporota,Arthur S. Slutsky +9 more
TL;DR: The updated and revised Berlin Definition for ARDS addresses a number of the limitations of the AECC definition and may serve as a model to create more accurate, evidence-based, critical illness syndrome definitions and to better inform clinical care, research, and health services planning.
Journal ArticleDOI
Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.
Maximilian Ackermann,Stijn E. Verleden,Mark Kuehnel,Axel Haverich,Tobias Welte,Florian Laenger,Arno Vanstapel,Christopher Werlein,Helge Stark,Alexandar Tzankov,William W. Li,Vincent W. Li,Steven J. Mentzer,Danny Jonigk +13 more
TL;DR: In this small series, vascular angiogenesis distinguished the pulmonary pathobiology of Covid-19 from that of equally severe influenza virus infection.
Journal ArticleDOI
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
Silvia Deaglio,Karen M. Dwyer,Wenda Gao,David J. Friedman,Anny Usheva,Anna Erat,Jiang-Fan Chen,Keiichii Enjyoji,Joel Linden,Mohamed Oukka,Vijay K. Kuchroo,Terry B. Strom,Simon C. Robson +12 more
TL;DR: It is concluded that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation.
Journal ArticleDOI
Phenotypic Heterogeneity of the Endothelium II. Representative Vascular Beds
TL;DR: The goal is to underscore the importance of site-specific properties of the endothelium in mediating homeostasis and focal vascular pathology, while at the same time emphasizing the value of approaching the endot Helium as an integrated system.