Journal ArticleDOI
Synthese und Reaktionen von 3‐Acyl‐2‐methylthio‐chromonen1)
Fritz Eiden,Gerd Rademacher +1 more
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TLDR
In this article, the 3-cyl-2-methylthio-chromone was shown to react with hydroxide or alkoxide ions or with amines to yield the substituted 3-acyl-4-hydroxycoumarins.Abstract:
Die 3-Acyl-2-methylthio-chromone 5a, 5c und 5d reagieren mit Hydroxid- und Alkoxidionen sowie Aminen unter Verdrangung der Methylthio-Gruppe zu den in 2-Stellung substituierten 3-Acyl-chromonen 8 und 10a–10p bzw. den 3-Acyl-4-hydroxy-cumarinen 6a und 6b. Mit Hydrazin, Hydroxylamin, o-Phenylendiamin, Guanidin und Amidin-Derivaten entstehen die anellierten Chromone 11a–11c, 12, 13 und 14a–14e..
Synthesis and Reactions of 3-Acyl-2-(methylthio)chromones
3-Acyl-2-(methylthio)chromones 5a, 5c and 5d react with hydroxide or alkoxide ions or with amines to yield the substituted 3-acylchromones 8, 10a–10p, or the 3-acyl-4-hydroxycoumarins 6a and 6b. With hydrazine, hydroxylamine, o-phenylenediamine, guanidine or amidine derivatives the fused chromones 11a–11c, 12, 13 and 14–14e are obtained.read more
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A versatile route to 2-alkyl-/aryl-amino-3-formyl- and hetero-annelated-chromones, through a facile nucleophilic substitution at C2 in 2-(N-methylanilino)-3-formylchromones
TL;DR: The N-methylanilino group in 2-(Nmethylonilino)-3-formylchromones, obtained in high yield by rearrangement of C(4-oxo-4H[1]-benzopyran-3-yl)-N-phenylnitrones to 2-anilino-3 -formyl-chromones followed by N-methylation, undergoes facile nucleophilic substitution by a variety of nitrogen nucleophiles, thereby paving the way for synthesis of novel 2-substituted
Patent
Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
TL;DR: In this article, the authors describe compounds of formula (I) which are useful in association with a pharmaceutical carrier as antiatherosclerotic agents. But they do not specify the type of carrier.
Journal ArticleDOI
Novel antiviral benzofuran-transition metal complexes.
Shadia A. Galal,Amira S. Abd El-All,Khaled H. Hegab,Asmaa A. Magd-El-Din,Nabil S. Youssef,H. I. El-Diwani +5 more
TL;DR: The HCV NS3-4A protease inhibitor activity of the tested compounds revealed that the complex formation had great positive effect on the bioactivity, where the Fe-complex 7 was the most potent compound with higher therapeutic index than VX-950, the standard.
Journal ArticleDOI
2-(N-Methylanilino)-3-formylchromone—a versatile synthon for incorporation of chromone moiety in a variety of heterocyclic systems and macrocycles through reactions with bifunctional nucleophiles
TL;DR: The reaction of 2-(N-methylanilino)-3-formylchromones with a number of bifunctional nucleophiles, involving substitution of N-methyl-lino moiety and/or condensations with 3-formedyl function have provided an easy access to a variety of potentially biologically active hetero-annelated chromones, novel macrocycles, and tetradentate ligands having intact chromone moiety as discussed by the authors.
Journal ArticleDOI
3-Acetyl-4-hydroxycoumarin: Synthesis, reactions and applications
TL;DR: The chemistry of 3-acetyl-4-hydroxycoumarin has gained increased interest in both synthetic organic and biological fields, since a large number of developments in the use of such compound seem to be of considerable value as mentioned in this paper.
References
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Journal ArticleDOI
Studies on antianaphylactic agents. 5. Synthesis of 3-(1H-tetrazol-5-yl)chromones, a new series of antiallergic substances.
TL;DR: A number of 3-(1H-tetrazol-5-yl)chromones were synthesized and found to have antiallergic activity in the rat passive cutaneous anaphylaxis (PCA) test and are of possible value for the treatment of asthma.
Journal ArticleDOI
Studies on antianaphylactic agents. 4. Synthesis and structure-activity relationships of 3-(4-oxo-4H-1-benzopyran-3)acrylic acids, a new series of antiallergic substances, and some related compounds
TL;DR: The syntheses of trans-3-(4-oxo-4H-1-benzypyran-3)acrylic acid and a number of analogs shown to be highly active in antiallergic bioassays are described and are of possible value in the treatment of asthma.
Journal ArticleDOI
Studies on 4-Hydroxycoumarins. XIII. The Mechanism for the Reaction of 4-Hydroxycoumarin with Aliphatic Acid Chlorides1
Journal ArticleDOI
Reaktionen von 3‐Acylchromonen mit Phenylhydrazin. 18. Mitt. über Untersuchungen an 4‐Pyronen
Fritz Eiden,H. Haverland +1 more
TL;DR: 3-Acylchromones (1, 13) react with phenylhydrazine forming pyrazole-derivatives (6, 8, 15) as discussed by the authors.
Journal ArticleDOI
Umlagerung von 3-Benzoylchromon in 3-Cyanflavon
Fritz Eiden,H. Haverland +1 more
TL;DR: Aus 3 C h r o m o n y l p h e l m e t h a n o r m e r m m e c l o r i d be im E r w g r m E n in E iner P y r i n A t H a n e c e t a n h a m e m e n e r e c h a t a c e m 3-Cyanf l avon ~) fiberein this article.