Journal ArticleDOI
Synthesis and Anticonvulsant Activity Evaluation of 6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines
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This article is published in Letters in Drug Design & Discovery.The article was published on 2011-09-30. It has received 8 citations till now.read more
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Recent developments on triazole nucleus in anticonvulsant compounds: a review
Mingxia Song,Xian-Qing Deng +1 more
TL;DR: This work is an attempt to systematically review the research of triazole derivatives in the design and development of anticonvulsant agents during the past two decades.
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Synthesis of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazides as antidepressants
TL;DR: A series of N′-arylidene-2-(5-aryl-1H-1, 2, 4-triazol-3-ylthio) acetohydrazide were synthesized as mentioned in this paper.
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Synthesis and Anticonvulsant Activity Evaluation of 3-alkoxy-4-(4- (hexyloxy/heptyloxy)phenyl)-4H-1,2,4 -triazole
TL;DR: Its potency against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline were established, with the results suggesting that GABA-mediated mechanisms might be involved in its anticonvulsant activity.
Journal ArticleDOI
Synthesis and anticonvulsant activity evaluation of 8-alkoxy-5-(4H-1,2,4-triazol-4-yl)quinoline derivatives
TL;DR: The potency of compound 4g against seizures induced by pentylenetetrazole, 3-mercaptopropionic acid, and bicuculline suggested its broad spectrum activity, and the mechanisms of action including inhibition of voltage-gated ion channels and modulation of GABAergic activity might involve in its anticonvulsant activity.
Journal ArticleDOI
Antitubercular and Anticonvulsant Activities of Phenyl-di-hydropyridazinone Derivatives Containing 2-Substituted amin-1-yl-methyl and 2-(2-1H-amin-1-yl) ethyl Moieties
Mohammad Asif,Mohd. Imran +1 more
TL;DR: Two series of 6-phenyl-4,5-dihydropyridazinone derivatives containing 2-substituted amin-1-yl-methyl and 5a-g were synthesized and tested as antitubercular and anticonvulsant agents and exhibited significant anti-tubercular activity.