Journal ArticleDOI
Synthesis and antioxidant evaluation of lipophilic oleuropein aglycone derivatives
Monica Nardi,Monica Nardi,S. Bonacci,L. Cariati,Paola Costanzo,Manuela Oliverio,Giovanni Sindona,Antonio Procopio +7 more
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TLDR
A set of oleuropein aglycone derivatives were synthesized by transacetylation under mild conditions with the aim of circumventing these drawbacks and making the active moiety in oleurpein suitable to be added to food fats.Abstract:
Oleuropein is the most important phenolic compound present in olive cultivars, but it is scarcely present in extra virgin olive oil (EVOO) due to its high hydrophilicity and degradability. Thus, a set of oleuropein aglycone derivatives were synthesized by transacetylation under mild conditions with the aim of circumventing these drawbacks and making the active moiety in oleuropein suitable to be added to food fats. The oleuropein aglycone (closed ring form) is obtained by hydrolyzing oleuropein using Lewis acid catalysis. Then, the permeation profiles as well as the antioxidant capacity of the oleuropein aglycone derivatives were evaluated by ORAC, DPPH assays and by ROS formation using the SH-SY5Y cell line. The biological activities of the obtained compounds exhibited a dependence on their level of lipophilicity.read more
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Improved Carotenoid Processing with Sustainable Solvents Utilizing Z-Isomerization-Induced Alteration in Physicochemical Properties: A Review and Future Directions.
Masaki Honda,Hakuto Kageyama,Takashi Hibino,Yelin Zhang,Wahyu Diono,Hideki Kanda,Ryusei Yamaguchi,Ryota Takemura,Tetsuya Fukaya,Motonobu Goto +9 more
TL;DR: The objective of this paper is to review the effect of Z-isomerization on the physicochemical properties of carotenoids and its application tocarotenoid processing, such as extraction, micronization, and emulsification, using sustainable solvents.
Journal ArticleDOI
Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates.
Luana Palazzi,Elena Bruzzone,Giovanni Bisello,Manuela Leri,Massimo Stefani,Monica Bucciantini,Patrizia Polverino de Laureto +6 more
TL;DR: It is shown that oleuropein aglycone (OleA), the main olive oil polyphenol, exhibits anti-amyloidogenic power in vitro by interacting with, and stabilizing, α-synuclein monomers thus hampering the growth of on-pathway oligomers and favouring thegrowth of stable and harmless aggregates with no tendency to evolve into other cytotoxic amyloids.
Journal ArticleDOI
Biorenewable Deep Eutectic Solvent for Selective and Scalable Conversion of Furfural into Cyclopentenone Derivatives
Maria Luisa Di Gioia,Monica Nardi,Paola Costanzo,Antonio De Nino,Loredana Maiuolo,Manuela Oliverio,Antonio Procopio +6 more
TL;DR: The tunable and selective conversion of biomass-produced furfural to cyclopentenone derivatives using a mixture of choline chloride and urea as a biorenewable deep eutectic solvent (DES) meets most of the criteria and can be considered as an environmental sustainable process in a natural reaction medium.
Journal ArticleDOI
Recent Developments in Metal-Based Drugs and Chelating Agents for Neurodegenerative Diseases Treatments
Thaís Aparecida Sales,Ingrid Guarnetti Prandi,Alexandre A. de Castro,Daniel H. S. Leal,Elaine F. F. da Cunha,Kamil Kuca,Teodorico C. Ramalho +6 more
TL;DR: This review seeks to discuss the different roles and recent developments of metal-based drugs, such as metal complexes and metal chelating agents as a proposal for the treatment of NDDs.
Journal ArticleDOI
Application of Natural Deep Eutectic Solvents in the Extraction of Quercetin from Vegetables.
Yunliang Dai,Kyung Ho Row +1 more
TL;DR: Choline chloride and betaine-based natural deep eutectic solvents were prepared using a heating method and applied to extract quercetin from onion and broccoli with ultrasonic-assisted solid liquid method coupled with HPLC.
References
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New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening
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Oxidative Stress, Inflammation, and Cancer: How Are They Linked?
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Journal ArticleDOI
Development and validation of an improved oxygen radical absorbance capacity assay using fluorescein as the fluorescent probe.
TL;DR: The improved ORAC(FL) assay provides a direct measure of hydrophilic chain-breaking antioxidant capacity against peroxyl radical and demonstrates that fluorescein (FL) is superior to B-phycoerythrin.