Synthesis and Biological Activity of Azine Heterocycle Functionalized Quaternary Phosphonium salts
Patil Akshay Ravindra,S. Karpagam +1 more
- Vol. 263, Iss: 2, pp 022017
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TLDR
Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides and showed excellent bactericidal activity against three Gram-positive bacteria and two Gram-negative bacteria.Abstract:
Various azine heterocycles (pyrazine, quinoxaline and quinoline) possessing phosphonium salts (3a-3c) were prepared as cationic biocides. The structural characterization of the phosphonium compounds was confirmed by FTIR, NMR and HR-Mass spectroscopy. These compounds has shown excellent bactericidal activity against two Gram-positive bacteria (Staphylococcus aureus, Bacillus subtilis) and two Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae). Quinoline functionalized phosphonium has shown more antibacterial activity than pyrazine and quinoxaline.read more
Citations
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Isosorbide Diallyl Based Antibacterial Thiol–Ene Photocured Coatings Containing Polymerizable Fluorous Quaternary Phosphonium Salt
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Quaternary phosphonium salts in the synthetic chemistry: Recent Progress, development, and Future Perspectives
TL;DR: In this article , the properties, synthesis, and applications of quaternary phosphonium salts in both homogeneous and heterogeneous catalysis forms are summarized, and they also discuss the asymmetric and asymmetric versions of the same compounds for phase-transfer catalysis into enantioselective organic reaction.
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Synthesis, molecular docking studies and ADME prediction of some new triazoles as potential antimalarial agents
Francis Klenam Kekessie,Cedric D. K. Amengor,Abena Amponsaa Brobbey,J Addotey,Cynthia Amaning Danquah,Paul Peprah,Benjamin Kingsley Harley,Inemesit Okon Ben,Felix Kwame Zoiku,Lawrence Sheringham Borquaye,Edward Ntim Gasu,Ebenezer Ofori-Attah,Michael Tetteh +12 more
TL;DR: In this paper, the authors report on the synthesis, characterization and antimalarial activity of a library of seven novel 1,2,3-triazoles as part of the drug discovery campaign against drug-resistant Plasmodium falciparum.
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Synthesis and antimicrobial activity of dimethyl- and trimethyl-substituted phosphonium salts with alkyl chains of various lengths.
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TL;DR: Although the soft analogs of the currently available hard antibacterial agents are shown to possess antibacterial activity in in vitro studies, it is likely that their in vivo activity will be hampered by their chemical instability.
Journal ArticleDOI
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