Journal ArticleDOI
Synthesis and biological activity of new arenediyne-linked isoxazolidines
Roberto Romeo,Michele Navarra,Salvatore V. Giofrè,Caterina Carnovale,Santa Cirmi,Giuseppe Lanza,Maria A. Chiacchio +6 more
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TLDR
Arenediyne-isoxazolidine conjugates have been synthesized as a new scaffold for the development of bioactive mimics and are endowed with antiproliferative activity against three human cancer cell lines.About:
This article is published in Bioorganic & Medicinal Chemistry.The article was published on 2014-07-01. It has received 22 citations till now. The article focuses on the topics: Biological activity & Bergman cyclization.read more
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NF-κB mediates the antiproliferative and proapoptotic effects of bergamot juice in HepG2 cells
Nadia Ferlazzo,Santa Cirmi,Marina Russo,Elena Trapasso,Maria Rita Ursino,Giovanni Enrico Lombardo,Sebastiano Gangemi,Gioacchino Calapai,Michele Navarra +8 more
TL;DR: The ability of BJ in reducing the growth of HepG2 cells is demonstrated, revealing its mechanism of action and suggesting a promising role as anticancer drugs.
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Moringin from Moringa Oleifera Seeds Inhibits Growth, Arrests Cell-Cycle, and Induces Apoptosis of SH-SY5Y Human Neuroblastoma Cells through the Modulation of NF-κB and Apoptotic Related Factors
Santa Cirmi,Nadia Ferlazzo,Agnese Gugliandolo,Laura Musumeci,Emanuela Mazzon,Alessia Bramanti,Michele Navarra +6 more
TL;DR: The ability of moringin to reduce the growth of SH-SY5Y cells is demonstrated and its mechanism of action is revealed, suggesting its promising role as an anticancer drug.
Journal ArticleDOI
Experimental and Theoretical DFT Study on Synthesis of Sterically Crowded 2,3,3,(4)5‐Tetrasubstituted‐4‐nitroisoxazolidines via 1,3‐Dipolar Cycloaddition Reactions Between Ketonitrones and Conjugated Nitroalkenes
TL;DR: In this paper, it was shown that 1,3-Dipolar cycloaddition reactions between ketonitrones and α-substituted nitroalkenes do not yield sterically crowded 2,3, 3, 5, 4, 4-nitroisoxazolidines.
Journal ArticleDOI
Synthesis and biological properties of 5-(1H-1,2,3-triazol-4-yl)isoxazolidines: a new class of C-nucleosides.
Salvatore V. Giofrè,Roberto Romeo,Caterina Carnovale,Raffaella Mancuso,Santa Cirmi,Michele Navarra,Adriana Garozzo,Maria A. Chiacchio +7 more
TL;DR: A novel series of C-nucleosides, featuring the presence of a 1,2,3-triazole ring linked to an isoxazolidine system, has been designed as mimetics of the pyrimidine nucleobases, and an antiproliferative effect was observed.
Journal ArticleDOI
Oxazole-Based Compounds As Anticancer Agents.
Maria A. Chiacchio,Giuseppe Lanza,Ugo Chiacchio,Salvatore V. Giofrè,Roberto Romeo,Daniela Iannazzo,Laura Legnani +6 more
TL;DR: The most recent reports on the use of oxazoles-based compounds in anticancer research are described, with reference to the new discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives.
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A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines
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Chemistry and Biology of the Enediyne Anticancer Antibiotics
Kyriacos C. Nicolaou,Wei-Min Dai +1 more