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Journal ArticleDOI

Synthesis and biological evaluation of some novel substituted 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamides

P Jaismy Jacob1, Anoop Thomas, S Venkataraman, E Hareeshbabu1, S L Manju 
01 Nov 2017-Vol. 263, Iss: 2, pp 022019
TL;DR: A novel class of substituted 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide synthesized by simple, modified Hantzsch condensation reaction using N-arylacetoacetamides, aryl aldehydes and ammonia exhibits significant antimicrobial activity along with antiulcer activity.
Abstract: A novel class of substituted 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxamide has been synthesized by simple, modified Hantzsch condensation reaction using N-arylacetoacetamides, aryl aldehydes and ammonia. Characterisation of the newly synthesized compounds was carried out by spectral analysis (IR, 1H NMR and Mass Spectroscopy). Antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans and antiulcer activity by aspirin induced and pyloric ligation ulcer model was studied. Results revealed that most of the compounds exhibit significant antimicrobial activity along with antiulcer activity. The compound 6i 4-dimethylamino phenyl group at 4th position of 1,4-dihydropyridine had shown 65% ulcer protection at 10 mg/kg administration in male albino rats.
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Book
01 Jan 1996
TL;DR: The Organization of the Clinical Bacteriology Laboratory: Quality Assurance and Safety in the Microbiology Laboratory, and some Selected Aspects of Light and Electronmicroscopy.
Abstract: PART a GENERAL SECTION: Organization of the Clinical Bacteriology Laboratory: Quality Assurance. Computers in Medical Microbiology. Safety in the Microbiology Laboratory. Laboratory Strategy in the Diagnosis of Infective Syndromes. Specimen Collection, Culture Containers and Media. Culture of Bacteria. Tests for the Identification of Bacteria. Laboratory Control of Antimicrobial Therapy. Some Serological Techniques for Microbial and Viral Infections. Nucleic Acid Techniques in Diagnostic Microbiology PART B BACTERIA and RELATED ORGANISMS: Staphylococcus: Cluster Forming Gram-Positive Cocci. Streptococcus and Enterococcus. Streptococcus Pneumoniae. Neisseria, Moraxella, Acinetobacter. Corynebacterium. Listeria, Erysipelothrix. Bacillus. Mycobacterium. Actinomycetes: Actinomyces, Actinomadra, Nocardia, Streptomyces and Related Genera. Enterobacteriacea: Escherichia, Kelbsiella, Proteus and Other Genera. Salmonella. Shigella. Psuedomonas, Stenotrophomas, Burkholderia. Vibrio: Aeromonas: Plesiomonas: Campylobacter: Arcobacter: Hel Icobacter: Wolinella. Haemophilus, Gardnerella and Other Bacilli. Bordetella. Brucella. Yersinia, Pasteurella, Francisella. Legionellaceae. Bacteroides, Fusobacterium and Other Gram-Negative Anaerobic Rods: Anaerobic Cocci: Identification of Anaerobes. Clostridia of Wound Infection. Enteropathogenic Clostridia and Clostridium Botulinum. Treponema: Serological Tests for Syphilis. Leptospira, Borrelia, Spirillum. Coxiella Burnetii and Other Medically Important Members for the Family Rickettsiaceae. Mycoplasma Pneumonaie and Other Medically Important Members of the Family Mycoplasmataceae. Chlamydia PART C VIRUSES: Laboratory Diagnosis of Virus Infections. Rapid Diagnosis of Viral Infections. Cell and Virus Culture PART D FUNGI: Fungi PART E PROTOZOA: Protozoa PART F HELMINTHS: Helminths PART G GENERAL METHODS: Immunofluorescence and Immunoelectronmicroscopy: Some Selected Aspects of Light and Electronmicroscopy. Staining Methods. Sterilization and Disinfection in the Laboratory. Ph Meas

516 citations

Journal ArticleDOI
TL;DR: To assess the specific role played by adrenals in the production of restraint ulcers in the stomach of albino rats, bilaterally adrenalectomized rats were exposed to stress by a restraint technique and the gastric ulcers that developed were compared with those of adrenal-intact rats under similar conditions.
Abstract: To assess the specific role played by adrenals in the production of restraint ulcers in the stomach of albino rats, bilaterally adrenalectomized rats were exposed to stress by a restraint technique...

111 citations

Journal ArticleDOI
TL;DR: A novel class of 4-aryl/heteroaryl-2,6-dimethyl-3,5-bis-N-(phenyl/substituted phenyl)-carbamoyl-1,4-dihydropyridines has been synthesized by simple, economical and eco-friendly, modified Hantzsch condensation reaction making use of N-arylacetoacetamides, aryl or heteroaryl aldehydes and ammonium

83 citations

Journal ArticleDOI
TL;DR: New derivatives of 1,4‐dihydropyridines bearing carbmethoxy and carbethoxy group at C‐3 and C‐5 of the 1,6‐dimethyl pyridine‐3,5‐dicarboxylate 4e are synthesized, making them more potent than first‐line antitubercular drug isoniazid.
Abstract: Recent studies showed that 1,4-dihydropyridine-3,5-dicarbamoyl derivatives with lipophilic groups have significant antitubercular activity In this study, we have synthesized new derivatives of 1,4-dihydropyridines bearing carbmethoxy and carbethoxy group at C-3 and C-5 of the 1,4-dihydropyridine ring In addition, 1H-pyrazole ring is substituted at C-4 position These analogues were synthesized by multi-component Hantzsch reaction The in vitro antitubercular activity of compounds against Mycobacterium tuberculosis H(37) Rv was evaluated The lowest minimum inhibitory concentration value, 002 μg/mL and SI > 500, was found for dimethyl 1,4-dihydro-4-(3-(4-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,6-dimethylpyridine-3,5-dicarboxylate 3f, diethyl 1,4-dihydro-4-(3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,6-dimethylpyridine-3,5-dicarboxylate 4c and diethyl 1,4-dihydro-4-(3-(4-bromophenyl)-1-phenyl-1H-pyrazol-4-yl)-2,6-dimethyl pyridine-3,5-dicarboxylate 4e, making them more potent than first-line antitubercular drug isoniazid In addition, these compounds exhibited relatively low cytotoxicity

32 citations

Journal ArticleDOI
TL;DR: Published data on oxidation of dihydropyridines and on the mechanisms and the role of hydride shifts in bioorganic chemistry, enantioselective synthesis and supramolecular chemistry are generalised.
Abstract: Published data on oxidation of dihydropyridines and on the mechanisms and the role of hydride shifts in bioorganic chemistry, enantioselective synthesis and supramolecular chemistry are generalised.

30 citations