Synthesis and reactions of halogen-containing chromones
TL;DR: In this paper, published data on the synthesis and reactivity of halogen-containing chromones, flavones, thiochromones and furochromones are generalised.
Abstract: Published data on the synthesis and reactivity of halogen-containing chromones, flavones, thiochromones and furochromones are generalised. The bibliography includes 220 references.
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TL;DR: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013) and SFRH/BD/61262/2009.
Abstract: This work was supported by the Foundation for Science and Technology (FCT), Portugal (projects PTDC/QUI-QUI/113687/2009 and PEst-C/QUI/UI0081/2013). A.G. (SFRH/BD/43531/2008) and M.J.M. (SFRH/BD/61262/2009) thank FCT for grants.
514 citations
TL;DR: Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals, and the scavenging effects of Cu( II) complex are stronger than Zn(II), Ni(II) complexes and some standard antioxidants, such as mannitol and vitamin C.
140 citations
TL;DR: Experimental results show that La (1), Sm (2), and Eu (4) complexes are better effective inhibitor for OH* than that of mannitol and indicates that the complexes have the activity to suppress O2-* and OH* and exhibit more effective antioxidants than ligand alone.
117 citations
TL;DR: An overview of the relevance of chromones as anti‐inflammatory agents, specifically as inhibitors of cyclooxygenase (COX), 5‐lipoxygenases (5‐LOX), interleukin‐5 (IL‐5), and nitric oxide (.NO) production is provided.
Abstract: The quest for safer anti-inflammatory drugs is still the focus of several medicinal chemistry programs. Chromones (4H-chromen-4-ones) are a group of naturally occurring compounds ubiquitous in plants, and the chromone core has proven to be a privileged scaffold in medicinal chemistry. Herein we provide an overview of the relevance of chromones as anti-inflammatory agents, specifically as inhibitors of cyclooxygenase (COX), 5-lipoxygenase (5-LOX), interleukin-5 (IL-5), and nitric oxide (. NO) production. Numerous structure-activity relationships and mechanisms of action are discussed. This review is therefore intended to provide a foundation for the design and synthesis of novel chromone-based compound libraries for further development into safer and more efficient anti-inflammatory agents.
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Book•
30 Sep 1997
TL;DR: In this article, the CHEC III is organized in 15 volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three and four-membered heterocycles, together with all fused systems containing a three- or four-measured heterocyclic ring.
Abstract: CHEC III is organized in 15 Volumes and closely follows the organization used in the previous edition: Volumes 1 and 2: Cover respectively three- and four-membered heterocycles, together with all fused systems containing a three- or four-membered heterocyclic ring. Volume 3: Five-membered rings with one heteroatom together with their benzo- and other carbocyclic-fused derivatives. Volumes 4, 5 and 6: Cover five-membered rings with two heteroatoms, and three or more heteroatoms, respectively, each with their fused carbocyclic compounds. Volumes 7, 8 and 9: Dedicated to six-membered rings with one, two, and more than two heteroatoms, respectively, again with the corresponding fused carbocylic compounds. Volumes 10, 11 and 12: Cover systems containing at least two directly fused heterocyclic five- and/or six-membered rings: of these Volume 10 deals with bi-heterocyclic rings without a ring junction heteroatom, and Volume 11 deals with 5:5 and 5:6 fused rings systems with at least one ring junction nitrogen, while Volume 12 is devoted to all other systems of five and/or six-membered fused or spiro heterocyclic rings with ring junction heteroatoms. Volumes 13 and 14: Seven-membered and larger heterocyclic rings including all their fused derivatives (except those containing three- or four-membered heterocyclic rings which are included in Volume 1 and 2, respectively). Volume 15: Author, ring and subject indexes.
8,174 citations
2,678 citations
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01 Jan 1961
TL;DR: In this article, it was shown that one of the most common types of known quantities of phenyl phenyl is phenyl oxide (POP) oxide, which is a phenyl-oxyoxy phenyl (PE)-oxyoxyphenyl) that can be obtained from phenyl compounds.
Abstract: A f t e r K e n d a l l ' s d i s c o v e r y [1] of the p h o t o g r a p h i c p r o p e r t i e s of 1 p h e n y l p r a z o l i d 3 o n e , m a n y s u b s t a n c e s of t h i s e l a s s b e c a m e known. A t t e m p t s w e r e m a d e to e l u c i d a t e t he r e l a t i o n s h i p b e t w e e n the s t r u c t u r e and p h o t o g r a p h i c p r o p e r t i e s of t h e s e s u b s t a n c e s [2, 3] and the m e c h a n i s m of t h e i r a c t i o n was s t u d i e d [4]. It was shown tha t t he r e a c t i o n c e n t e r in the m o l e cu le of a 1 a r y l p y r a z o l i d o n e in t he d e v e l o p m e n t p r o c e s s is t he p y r a z o l i d o n e r i n g [4, 5]. The o b j e c t of t he p r e s e n t w o r k w a s the s y n t h e s i s of s u b s t a n c e s t he m o l e e u l e s of wh ich would con t a in two p y r a z o l i d o n e r i n g s . T h e s e s u b s t a n c e s could be of i n t e r e s t in the d e v e l o p m e n t of l i g h t s e n s i t i v e c i n e m a t o g r a p h i c m a t e r i a l s . The s y n t h e s i s of the f i r s t r e p r e s e n t a t i v e s of t h i s c l a s s t h a t we have e f f e c t e d [6] s t a r t e d f r o m di ( 4 a m i n o phenyl) ox ide and 1, 2 d i ( 4 a m i n o p h e n y l ) e t h a n e .
2,673 citations
TL;DR: The wide synthetic potential of levulinic acid, particularly as a key compound in the synthesis of various heterocyclic systems, saturated and unsaturated ketones and diketones, difficultly accessible acids and other compounds is demonstrated in this article.
Abstract: Data concerning the methods of synthesis, chemical transformations and application of levulinic acid are analysed and generalised. The wide synthetic potential of levulinic acid, particularly as a key compound in the synthesis of various heterocyclic systems, saturated and unsaturated ketones and diketones, difficultly accessible acids and other compounds is demonstrated. The accessibility of levulinic acid from hexose-containing wood-processing and agricultural wastes is noted. The bibliography includes 260 references.
140 citations