Journal ArticleDOI
Synthesis, antimycobacterial activity evaluation, and QSAR studies of chalcone derivatives.
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TLDR
In order to develop relatively small molecules as antimycobacterial agents, twenty-five chalcones were synthesized, their activity was evaluated, and quantitative structure-activity relationship (QSAR) was developed.About:
This article is published in Bioorganic & Medicinal Chemistry Letters.The article was published on 2007-03-15. It has received 113 citations till now. The article focuses on the topics: Antimycobacterial & Quantitative structure–activity relationship.read more
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Synthesis, antioxidant evaluation, and quantitative structure–activity relationship studies of chalcones
TL;DR: In this article, the synthesis, antioxidant activity, and quantitative structure-activity relationship (QSAR) of 25 chalcone derivatives were reported, which were synthesized by the Claisen-Schmidt reaction and were characterized by FTIR, NMR, and mass spectroscopy.
Journal ArticleDOI
Synthesis and pharmacological properties of chalcones: a review
Santosh L. Gaonkar,U. N. Vignesh +1 more
TL;DR: A review of the synthesis and pharmacological properties of chalcone derivatives highlights the important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral,Anti-inflammatory, antioxidant, antileishmanial anti-tumor, and anticancer properties.
Journal ArticleDOI
Synthesis, antibacterial activity evaluation and QSAR studies of novel dispiropyrrolidines.
TL;DR: Topology, shape, charge distribution and hydrophobic nature of the molecules had pronounced effect on the antibacterial activity of these dispiropyrrolidines.
Journal ArticleDOI
Synthesis, Biological Evaluation, And Molecular Modeling of Chalcone Derivatives As Potent Inhibitors of Mycobacterium tuberculosis Protein Tyrosine Phosphatases (PtpA and PtpB)
Louise Domeneghini Chiaradia,Priscila Graziela Alves Martins,Marlon Norberto Sechini Cordeiro,Rafael Victorio Carvalho Guido,Gabriela Ecco,Adriano D. Andricopulo,Rosendo A. Yunes,Javier Vernal,Ricardo José Nunes,Hernán Terenzi +9 more
TL;DR: Molecular modeling investigations were carried out with the aim of revealing the most relevant structural requirements underlying the binding affinity and selectivity of this series of inhibitors as potential anti-TB drugs.
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Synthesis of quinoline coupled [1,2,3]-triazoles as a promising class of anti-tuberculosis agents
TL;DR: The efficiency and fidelity of the Cu(I)-catalyzed azide-alkyne reaction are substantiated by good yields and exclusive formation of the expected 1,4-disubstituted triazole product.
References
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TL;DR: This Users guide notations acronyms list of molecular descriptors contains abbreviations for molecular descriptor values that are useful for counting and topological descriptors calculation.
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Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence
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Identification of nitric oxide synthase as a protective locus against tuberculosis
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The Mycobacterium avium complex.
TL;DR: The successful treatment of MAC disease clearly will require an early and rapid detection of the MAC in clinical specimens long before the establishment of the characteristic overwhelming infection of bone marrow, liver, spleen, and other tissue.