Patent•
Synthesis method of aryl ketone compounds
04 Mar 2015-
TL;DR: In this paper, a synthesis method of aryl ketone compounds, which comprises of the following step: in a reaction solvent, reacting nitrile compounds with a rryl boric acid in the presence of a palladium catalyst, a ligand and an accelerator, was presented.
Abstract: The invention relates to a synthesis method of aryl ketone compounds, which comprises the following step: in a reaction solvent, reacting nitrile compounds with aryl boric acid in the presence of a palladium catalyst, a ligand and an accelerator to obtain the aryl ketone compounds. The method has the advantages of simple reaction and high yield, is simple to operate, is a brand-new synthesis method of aryl ketone compounds, provides a new synthesis route for synthesis of the aryl ketone compounds, and has favorable scientific research value and industrialization potential.
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Patent•
15 Jun 2018
TL;DR: In this paper, a method for synthesizing a pyrrole derivative represented by a formula (6) has been proposed, which has a reaction route and a bran-new synthesis method and synthesis route.
Abstract: The invention relates to a method for synthesizing a pyrrole derivative represented by a formula (6) shown in the description The synthesis method has a reaction route shown in the description The synthesis method comprises the following steps: S1: subjecting a compound represented by a formula (3) shown in the description to a self-cyclization reaction in the presence of an oxidant in an organic solvent, and carrying out aftertreatment after the reaction ends, so as to obtain a compound represented by a formula (4) shown in the description; and S2: subjecting the compound represented by theformula (4) and a compound represented by a formula (5) shown in the description to a reaction in the presence of a palladium catalyst, an organic ligand and an acidic compound in a solvent in a nitrogen atmosphere, and carrying out aftertreatment after the reaction ends, so as to obtain a compound represented by a formula (6) shown in the description According to the method, through creativelyoptimizing a plurality of technical features of each step, a bran-new synthesis method and synthesis route are provided for preparing this kind of compounds, and thus, the method has a good industrialization prospect and a potential application value
References
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TL;DR: Alkyl aryl ketones were synthesized by the carbonylative cross-coupling reaction of alkyl iodides and aryLboronic acids under combined Pd/light conditions.
68 citations
TL;DR: Using moelcular oxygen as the terminal oxidant, various aryl halide-containing beta-aryl ketones and aldehydes can be synthesized directly from readily available allyic alcohols and boronic acids via palladium-catalyzed oxidative crosscoupling reactions as mentioned in this paper.
Abstract: Using moelcular oxygen as the terminal oxidant, various aryl halide-containing beta-aryl ketones and aldehydes can be synthesized directly from readily available allyic alcohols and boronic acids via palladium-catalyzed oxidative cross-coupling reactions. The dual roles of copper, including electron-carrier and Lewis acid functions, are supposed to be critical for the high reactivity and selectivity of this aerobic oxidative coupling transformation.
41 citations
Patent•
15 Sep 2010
TL;DR: In this article, a method for preparing alpha-aryl ketones compounds by adopting a one-pot method and using low-cost easily available aromatic aldehyde and halogenated hydrocarbon as starting raw materials under the participation of organic micromolecular N-heterocyclic carbene was presented.
Abstract: The invention relates to a method for preparing alpha-aryl ketones compounds by adopting a one-pot method and using low-cost easily-available aromatic aldehyde and halogenated hydrocarbon as starting raw materials under the participation of organic micromolecular N-heterocyclic carbene. The method has the advantages of simple operation, mild preparation condition, easy massive commercial preparation and the like, and overcomes the defects that precious metals are used as catalysts and the preparation condition is serious and the like in the prior art.
2 citations