Synthesis of 4-phenylcoumarins from Dalbergia volubilis and Exostema caribaeum
TL;DR: Two isomeric 4-phenyl coumarins, 3′,7-dihydroxy-4′,5-dimethoxy-4]-phenylcoumarin seshadrin from Dalbergia volubilis, and 3'',5]-dimethyl-4'',7]-dimethyltimethoxy 4'',4''-4´,7'' coumarin from Exostema caribaeum have been synthesized.
About: This article is published in Phytochemistry.The article was published on 1991-01-01. It has received 19 citations till now. The article focuses on the topics: Dalbergia.
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Patent•
09 Feb 2004
TL;DR: In this paper, compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
8 citations
TL;DR: Based on the cabozantinib scaffold, novel c‐Met inhibitors were rationalized from the limited knowledge of structure‐activity relationships for the quinoline 6‐position, where additional hydrogen bonding was identified in the enzymatic pocket for the para‐amino substituted 15b and 18b.
Abstract: Based on the cabozantinib scaffold, novel c-Met inhibitors were rationalized from the limited knowledge of structure-activity relationships for the quinoline 6-position. Emphasis was given to modifications capable of engaging in additional polar interactions with the c-Met active site. In addition, ortho-fluorinations of the terminal benzene ring were explored. Fifteen new molecules were synthesized and evaluated in a c-Met enzymatic binding assay. A wide range of substituents were tolerated in the quinoline 6-position, while the ortho-fluorinations performed were shown to give considerable reductions in the c-Met binding affinity. The antiproliferative effects of the compounds were evaluated in the NCI60 cancer cell line panel. Most notably, compounds 15b and 18b were able to inhibit cell proliferation more efficiently than cabozantinib in leukemia, CNS, and breast cancer cell lines. The in vitro data agreed well with the in silico docking results, where additional hydrogen bonding was identified in the enzymatic pocket for the para-amino substituted 15b and 18b.
6 citations
Patent•
02 Jul 2007
TL;DR: In this article, compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
5 citations
TL;DR: Ferric chloride catalyses the condensation of phenols with alkylcinnamates to produce 3,4-dihydro-4-arylcoumarins as mentioned in this paper.
Abstract: Ferric chloride catalyses the condensation of phenols with alkylcinnamates to produce 3,4-dihydro-4-arylcoumarins
5 citations
Patent•
28 Oct 2003
TL;DR: In this article, compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
Abstract: Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.
3 citations
References
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19 citations
TL;DR: In this article, 8-(γ,γ-dimethyl-allyl)-1-Methoxycoumestrol has been isolated from the roots of Lotus creticus along with some known compounds.
16 citations
TL;DR: The structure of exostemin, a constituent isolated from the benzene extract of the Mexican plant Exostemma caribaeum (Rubiaceae), has been established as 8-hydroxy-5,7-dimethoxy-4-(p -methoxyphenyl) coumarin (I).
14 citations