Journal ArticleDOI
Synthesis of cyclic 2-enones from cyclic 1,3-diketones
Gene A. Hiegel,Patrick Lee Burk +1 more
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This article is published in Journal of Organic Chemistry.The article was published on 1973-10-01. It has received 29 citations till now.read more
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Journal ArticleDOI
Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.
Kenneth He Huang,James Marvin Veal,Patrick Fadden,John W. Rice,Jeron Eaves,Jon-Paul Strachan,Amy F. Barabasz,Briana Foley,Barta Thomas E,Wei Ma,Melanie Silinski,Mei Hu,Jeffrey M. Partridge,Anisa Scott,Laura G. Dubois,Tiffany Freed,Paul M. Steed,Andy J. Ommen,Emilie D. Smith,Philip F. Hughes,Angela R. Woodward,Hanson Gunnar J,W. Stephen Mccall,Christopher John Markworth,Lindsay Hinkley,Matthew Jenks,Geng Lifeng,Meredith Lewis,James C. Otto,Bert Pronk,Katleen Verleysen,Steven E. Hall +31 more
TL;DR: A novel class of heat shock protein 90 (Hsp90) inhibitors was developed from an unbiased screen to identify protein targets for a diverse compound library, and optimized analogues exhibited nanomolar antiproliferative activity across multiple cancer cell lines.
Journal ArticleDOI
Design, synthesis, and evaluation of small molecule Hsp90 probes
Tony Taldone,Danuta Zatorska,Pallav D. Patel,Hongliang Zong,Anna Rodina,James H. Ahn,Kamalika Moulick,Monica L. Guzman,Gabriela Chiosis +8 more
TL;DR: The synthesis of chemical tools for three Hsp90 inhibitor classes will be useful for probing tumor-by-tumor the HSp90 complexes isolated by specific inhibitors, and will lead to better understanding of tumor specific molecular markers to aid in their clinical development.
Journal ArticleDOI
A regioselective and stereospecific synthesis of allylsilanes from secondary allylic alcohol derivatives
TL;DR: In this paper, the reaction of the silyl-cuprate with allylic esters and the three-step sequence with the carbamates is stereo-chemically complementary.
Journal ArticleDOI
New oxidative demetalation protocol for molybdenum π-complexes: Enantiocontrolled synthesis of unsaturated ketones and lactones
TL;DR: An efficient and general oxidative demetalation of (eta(3)-allyl)molybdenum complexes using pyridinium dichromate allows the introduction of a carbonyl group at an allylic terminus of the pi-system.
Book ChapterDOI
Chapter 1 Dimedone: A Versatile Precursor for Annulated Heterocycles
El Sayed H. El Ashry,El Sayed H. El Ashry,Laila F. Awad,Yeldez El Kilany,El-Sayed I. Ibrahim +4 more
TL;DR: The chapter illustrates that dimedone's structural features and its reactivity to form more functionalized derivatives have led to the construction of a wide range of fused or spiral biheterocycles.