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Journal ArticleDOI

Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

01 Apr 2020-Journal of Heterocyclic Chemistry (John Wiley & Sons, Ltd)-Vol. 57, Iss: 4, pp 1476-1523
About: This article is published in Journal of Heterocyclic Chemistry.The article was published on 2020-04-01. It has received 33 citations till now.
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TL;DR: In this paper, the strategies toward scaling up find an ally in continuous-flow reactor technology comparing dielectric and conductive heating, which has been widely studied and deliberated, opening up some controversial issues as well.
Abstract: Microwave-assisted organic synthesis has been widely studied and deliberated, opening up some controversial issues as well. Nowadays, microwave chemistry is a mature technology that has been well demonstrated in many cases with numerous advantages in terms of the reaction rate and yield. The strategies toward scaling up find an ally in continuous-flow reactor technology comparing dielectric and conductive heating.

31 citations

Journal ArticleDOI
TL;DR: In this article, the authors present a survey of visible light mediated functionalization reactions of alkynes, wherein they have been transformed into α-oxo compounds, β-keto sulfoxides, substituted olefins, N-heterocycles, internal alkynes and sulfur containing compounds.

16 citations

Journal ArticleDOI
TL;DR: The potent compound 11 (RV59, NSC763967) showed broad-spectrum cytotoxicity against different types of cancer cells, while being less cytotoxic than doxorubicin towards different normal cells (SV-HUC-1, WMPY- 1, and RWPE-1).

10 citations

Journal ArticleDOI
TL;DR: The efficiency of the Knoevenagel condensation explored in the past six‐year to generate molecules of pharmacological interest, predominantly toward cancer is underscored.
Abstract: Knoevenagel condensation is an entrenched, prevailing, prominent arsenal following greener principles in the generation of α, β‐unsaturated ketones/carboxylic acids by involving carbonyl functionalities and active methylenes. This reaction has proved to be a major driving force in many multicomponent reactions indicating the prolific utility toward the development of biologically fascinating molecules. This eminent reaction was acclimatised on different pharmacophoric aldehydes (benzimidazole, β‐carboline, phenanthrene, indole, imidazothiadiazole, pyrazole etc.) and active methylenes (oxindole, barbituric acid, Meldrum's acid, thiazolidinedione etc.) to generate the library of chemical compounds. Their potential was also explicit to understand the significance of functionalities involved, which thereby evoke further developments in drug discovery. Furthermore, most of these reaction products exhibited remarkable anticancer activity in nanomolar to micromolar ranges by targeting different cancer targets like DNA, microtubules, Topo‐I/II, and kinases (PIM, PARP, NMP, p300/CBP) etc. This review underscores the efficiency of the Knoevenagel condensation explored in the past six‐year to generate molecules of pharmacological interest, predominantly toward cancer. The present review also provides the aspects of structure‐activity relationships, mode of action and docking study with possible interaction with the target protein.

7 citations

References
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Journal ArticleDOI
TL;DR: Overall, gas adsorption measurements on desolvated framework SOF-1a reveal not only high capacity uptakes for C(2)H(1) and CO(2), compared to other crystalline molecular organic solids, but also an adsorptive selectivity in the order C( 2)H (2) > CO(3) > CH(4) > N(2).
Abstract: Reaction of β-amino-β-(pyrid-4-yl)acrylonitrile with the aromatic dicarboxaldehydes 9,10-bis(4-formylphenyl)anthracene and terephthalaldehyde affords the dihydropyridyl products 9,10-bis(4-((3,5-dicyano-2,6-dipyridyl)dihydropyridyl)phenyl)anthracene (L1) and 1,4-bis(4-(3,5-dicyano-2,6-dipyridyl)dihydropyridyl)benzene (L2), respectively. In the solid state [L1]·2.5DMF·3MeOH (SOF-1) crystallizes in the monoclinic space group P21/c and forms a 3D stable supramolecular organic framework via strong N−H···Npy hydrogen bonds and π−π interactions. The material incorporates pyridyl-decorated channels and shows permanent porosity in the solid state. The pore volumes of the desolvated framework SOF-1a calculated from the N2 isotherm at 125 K and the CO2 isotherm at 195 K are 0.227 and 0.244 cm3 g−1, respectively. The N2 absorption capacity of SOF-1a at 77 K is very low, with an uptake of 0.63 mmol g−1 at 1 bar, although saturation N2 adsorption at 125 K is 6.55 mmol g−1 (or 143 cm3 g−1). At ambient temperature, SOF-...

306 citations

Journal ArticleDOI
Yu‐Ling Li1, Hui Chen1, Chunling Shi1, Daqing Shi1, Shun-Jun Ji1 
TL;DR: An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported.
Abstract: An efficient one-pot synthesis of spirooxindole derivatives by three-component reaction of isatins, malononitrile (cyanoacetic ester) and 1,3-dicarbonyl compounds in water in the presence of l-proline is reported This new protocol has the advantages of environmental friendliness, higher yields, shorter reaction times, low cost, and convenient operation

245 citations