Journal ArticleDOI
Synthesis of l-α-amino-ω-bromoalkanoic acid for side chain modification
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In this article, the synthesis of non-natural amino acids with side chain lengths varying from 4 to 10 methylene units has been studied and shown to be useful intermediates for functionalization.About:
This article is published in Tetrahedron Letters.The article was published on 2004-01-12. It has received 22 citations till now. The article focuses on the topics: Cyclic peptide & Side chain.read more
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Traversing the coordination chemistry and chemical biology of hydroxamic acids
TL;DR: In this article, X-ray crystallographic data from 25 hydroxamato and 17 hydroximato mononuclear non-oxo-containing complexes with bidentate O, O 'coordination from monohydroxamic acids was analyzed.
Journal ArticleDOI
Highly potent and selective histone deacetylase 6 inhibitors designed based on a small-molecular substrate.
Takayoshi Suzuki,Akiyasu Kouketsu,Yukihiro Itoh,Shinya Hisakawa,Satoko Maeda,Minoru Yoshida,Hidehiko Nakagawa,Naoki Miyata +7 more
TL;DR: Thiolate analogues designed based on the structure of an HDAC6-selective substrate and evaluated the histone/alpha-tubulin acetylation selectivity by Western blot analysis found novel histone deacetylase 6 (HDAC6)-selective inhibitors.
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Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones.
TL;DR: Cyclic tetrapeptides containing trifluoromethyl and pentafluoroethyl ketone as zinc binding functional group were synthesized as potent HDAC inhibitors and showed to be promising anticancer agents.
Journal ArticleDOI
Biological evaluation of dodecaborate-containing L-amino acids for boron neutron capture therapy.
Yoshihide Hattori,Shintaro Kusaka,Mari Mukumoto,Kouki Uehara,Tomoyuki Asano,Minoru Suzuki,Shin-ichiro Masunaga,Koji Ono,Shinji Tanimori,Mitsunori Kirihata +9 more
TL;DR: In this article, the cytotoxicity, incorporation amounts into tumor cells, and the tumor cell killing effects of these compounds were elucidated to evaluate their usefulness as boron carriers.
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An efficient access to both enantiomers of pipecolic acid
Louis A. Watanabe,Saori Haranaka,Binoy Jose,Minoru Yoshida,Tamaki Kato,Mitsuaki Moriguchi,Kenji Soda,Norikazu Nishino +7 more
TL;DR: An efficient and convenient synthesis of both enantiomers of pipecolic acid has been developed using the intramolecular cyclization of 2-amino-6-bromohexanoic acid under mild conditions.
References
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Journal ArticleDOI
Über neue organische Phosphorverbindungen III. Phosphinmethylenderivate und Phosphinimine
Hermann Staudinger,Jules Meyer +1 more
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Synthesis and structure-activity relationships of antibacterial phosphonopeptides incorporating (1-aminoethyl)phosphonic acid and (aminomethyl)phosphonic acid.
TL;DR: In this paper, a method for large-scale synthesis of the potent antibacterial agent L-Ala-L -Ala(P) (1, Alafosfalin) is described.
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Site-specific protein immobilization by Staudinger ligation.
TL;DR: The Staudinger ligation between an azido-protein and a phosphinothioester-derivatized surface is demonstrated to be an effective means for the site-specific, covalent immobilization of a protein.
Journal ArticleDOI
Protein-tyrosine phosphatases: structure, mechanism, and inhibitor discovery.
TL;DR: Current understandings of PTP structure and mechanism of catalysis and the relationship of these to PTP inhibitor development are summarized and inhibitors that utilize a more structure‐based rationale are presented.
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Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action.
S. De Lombaert,L. Blanchard,Lisa B. Stamford,Jenny Tan,Eli M. Wallace,Yoshitaka Satoh,John Fitt,Daniel Hoyer,D. Simonsbergen,John Moliterni,N. Marcopoulos,Paula Savage,Mary Chou,Angelo J. Trapani,Arco Y. Jeng +14 more
TL;DR: Functionally, 27 and 29 were the two most efficacious compounds from this study, producing sustained inhibition of ECE-1 activity in rats, as measured by their ability to block the hypertensive effects induced by big ET-1.