Synthesis, properties, and biomedical applications of gelatin methacryloyl (GelMA) hydrogels
Kan Yue,Kan Yue,Grissel Trujillo-de Santiago,Grissel Trujillo-de Santiago,Mario Moises Alvarez,Ali Tamayol,Ali Tamayol,Nasim Annabi,Nasim Annabi,Nasim Annabi,Ali Khademhosseini,Ali Khademhosseini,Ali Khademhosseini +12 more
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TLDR
Gelatin methacryloyl (GelMA) hydrogels have been widely used for various biomedical applications due to their suitable biological properties and tunable physical characteristics and are demonstrated in a wide range of tissue engineering applications including engineering of bone, cartilage, cardiac, and vascular tissues, among others.About:
This article is published in Biomaterials.The article was published on 2015-12-01 and is currently open access. It has received 1646 citations till now. The article focuses on the topics: Self-healing hydrogels.read more
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Bioinks for 3D bioprinting: an overview
P. Selcan Gungor-Ozkerim,P. Selcan Gungor-Ozkerim,Ilyas Inci,Ilyas Inci,Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Ali Khademhosseini,Mehmet R. Dokmeci +8 more
TL;DR: In this review, an in-depth discussion of the different bioinks currently employed for bioprinting are provided, and some future perspectives in their further development are outlined.
Journal ArticleDOI
Direct 3D bioprinting of perfusable vascular constructs using a blend bioink
Weitao Jia,Weitao Jia,Weitao Jia,P. Selcan Gungor-Ozkerim,P. Selcan Gungor-Ozkerim,Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Kan Yue,Kan Yue,Kai Zhu,Kai Zhu,Kai Zhu,Wanjun Liu,Wanjun Liu,Qingment Pi,Qingment Pi,Batzaya Byambaa,Batzaya Byambaa,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Su Ryon Shin,Su Ryon Shin,Su Ryon Shin,Ali Khademhosseini +25 more
TL;DR: A versatile 3D bioprinting strategy that employs biomimetic biomaterials and an advanced extrusion system to deposit perfusable vascular structures with highly ordered arrangements in a single-step process, superior to conventional microfabrication or sacrificial templating approaches for fabrication of the perfusable vasculature.
Journal ArticleDOI
Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip.
Yu Shrike Zhang,Yu Shrike Zhang,Yu Shrike Zhang,Andrea Arneri,Simone Bersini,Su Ryon Shin,Kai Zhu,Zahra Goli-Malekabadi,Julio Aleman,Cristina Colosi,Fabio Busignani,Valeria Dell’Erba,Colin E. Bishop,Thomas Shupe,Danilo Demarchi,Matteo Moretti,Marco Rasponi,Mehmet R. Dokmeci,Anthony Atala,Ali Khademhosseini +19 more
TL;DR: It is demonstrated that the method for generation of endothelialized organoids fabricated through an innovative 3D bioprinting technology may find widespread applications in regenerative medicine, drug screening, and potentially disease modeling.
Journal ArticleDOI
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
Guoyou Huang,Fei Li,Xin Zhao,Yufei Ma,Yuhui Li,Min Lin,Guorui Jin,Tian Jian Lu,Guy M. Genin,Feng Xu +9 more
TL;DR: This review encapsulates where recent advances appear to leave the ever-shifting state of the art in the cell microenvironment, and it highlights areas in which substantial potential and uncertainty remain.
Journal ArticleDOI
Gelatin-Methacryloyl Hydrogels: Towards Biofabrication-Based Tissue Repair.
Barbara J. Klotz,Debby Gawlitta,Antoine J.W.P. Rosenberg,Jos Malda,Ferry P.W. Melchels,Ferry P.W. Melchels +5 more
TL;DR: G gelatin-methacryloyl (gelMA) hydrogels have recently gained increased attention and could be used to accelerate the development of clinically relevant applications.
References
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Jason W. Nichol,Sandeep T. Koshy,Sandeep T. Koshy,Sandeep T. Koshy,Hojae Bae,Hojae Bae,Chang M. Hwang,Chang M. Hwang,Seda Yamanlar,Seda Yamanlar,Ali Khademhosseini,Ali Khademhosseini +11 more
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TL;DR: A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix that open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.
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25th Anniversary Article: Rational Design and Applications of Hydrogels in Regenerative Medicine
Nasim Annabi,Nasim Annabi,Ali Tamayol,Ali Tamayol,Jorge Alfredo Uquillas,Jorge Alfredo Uquillas,Mohsen Akbari,Mohsen Akbari,Luiz E. Bertassoni,Luiz E. Bertassoni,Chaenyung Cha,Chaenyung Cha,Gulden Camci-Unal,Gulden Camci-Unal,Mehmet R. Dokmeci,Mehmet R. Dokmeci,Nicholas A. Peppas,Ali Khademhosseini,Ali Khademhosseini +18 more
TL;DR: The development of advanced hydrogel with tunable physiochemical properties is highlighted, with particular emphasis on elastomeric, light‐sensitive, composite, and shape‐memory hydrogels, and a number of potential applications and challenges in the utilization in regenerative medicine are reviewed.
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Structural and rheological properties of methacrylamide modified gelatin hydrogels.
TL;DR: The results indicate that the rheological properties of the gelatin-based hydrogels can be controlled by the degree of substitution, polymer concentration, initiator concentration, and UV irradiation conditions.
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Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility.
Benjamin D. Fairbanks,Michael P. Schwartz,Christopher N. Bowman,Kristi S. Anseth,Kristi S. Anseth +4 more
TL;DR: A water soluble lithium acylphosphinate salt is evaluated for its ability to polymerize diacrylated poly(ethylene glycol) (PEGDA) monomers rapidly into hydrogels, while maintaining high viability during direct encapsulation of cells.