Synthesis, spectroscopic and crystal structure of nickel(II) complex of thiosemicarbazone basedSchiff base: Antimicrobial, anticancer and molecular docking studies
TL;DR: In this paper, a new thiosemicarbazone based ligand synthesized by the facile condensation reaction of 3-ethoxy salicylaldehyde and 4-phenylthiosembrazide was used to characterize the ligand and Ni(II) complex.
About: This article is published in Inorganic Chemistry Communications.The article was published on 2021-10-01. It has received 3 citations till now. The article focuses on the topics: Ligand (biochemistry).
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TL;DR: In this paper , the authors proposed large-scale and rapid extraction of uranium from seawater is promising for overcoming the challenge of supply interruption to achieve sustainable nuclear energy production, however, existing uranium adsorbents are limited by...
Abstract: Large-scale and rapid extraction of uranium from seawater is promising for overcoming the challenge of supply interruption to achieve sustainable nuclear energy production. However, existing uranium adsorbents are limited by...
1 citations
TL;DR: In this article , the bidentate ligand thiosemicarbazone (H3L) and its Ni(II) complex were synthesized and characterized by single crystal X-ray diffraction and various spectroscopic methods.
TL;DR: In this paper , a quasi-reversible Ni(II)/Ni(I) redox system was investigated by utilizing density functional theory (DFT) calculations with the Becke 3-Lee-Yang-Parr (B3LYP) method employing the LANL2DZ basis set.
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TL;DR: Two freely available web servers for molecular docking that perform structure prediction of protein–protein and protein–small molecule complexes and the SymmDock method predicts the structure of a homomultimer with cyclic symmetry given theructure of the monomeric unit are described.
Abstract: Here, we describe two freely available web servers for molecular docking. The PatchDock method performs structure prediction of protein-protein and protein-small molecule complexes. The SymmDock method predicts the structure of a homomultimer with cyclic symmetry given the structure of the monomeric unit. The inputs to the servers are either protein PDB codes or uploaded protein structures. The services are available at http://bioinfo3d.cs.tau.ac.il. The methods behind the servers are very efficient, allowing large-scale docking experiments.
2,590 citations
TL;DR: The biotech industry is establishing itself as the discovery arm of the pharmaceutical industry, and in bridging the gap between academia and large pharmaceutical companies, the biotech firms have been effective instruments of technology transfer.
Abstract: Driven by chemistry but increasingly guided by pharmacology and the clinical sciences, drug research has contributed more to the progress of medicine during the past century than any other scientific factor. The advent of molecular biology and, in particular, of genomic sciences is having a deep impact on drug discovery. Recombinant proteins and monoclonal antibodies have greatly enriched our therapeutic armamentarium. Genome sciences, combined with bioinformatic tools, allow us to dissect the genetic basis of multifactorial diseases and to determine the most suitable points of attack for future medicines, thereby increasing the number of treatment options. The dramatic increase in the complexity of drug research is enforcing changes in the institutional basis of this interdisciplinary endeavor. The biotech industry is establishing itself as the discovery arm of the pharmaceutical industry. In bridging the gap between academia and large pharmaceutical companies, the biotech firms have been effective instruments of technology transfer.
2,551 citations
TL;DR: Rhodac, a tetramethinemeromonomethine rhodacyanine dye with an absorption maximum of 655 nm (ethanol) and a molar absorption coefficient epsilon = 108000 shows very promising photo-dependent biological activity.
Abstract: The present work has been carried out to explore the potential application of cyanines in photodynamic therapy. After photosensitization, the in vitro cytotoxic and antiproliferative activity on HeLa cells of a total of 35 cyanines belonging to several chemical subgroups is explored. Most of these cyanines have never been used before in similar experimental work. From a first set of experiments, it is found that none of the krypto-, oxa- and imidacyanines is photobiologically active on HeLa cells. Conversely, five thiacyanines (Thiac1–5), one rhodacyanine (Rhodac) and four indocyanines (Indoc2, Indoc4, Indoc5, Indoc7) show photodependent cytotoxicity or antiproliferative effects. A more detailed study shows that out of the ten selected compounds, eight cyanines feature significant photodependent cytotoxic and antiproliferative effects. All possess maximum absorption ranges between 545 and 824 nm. In particular, Rhodac, a tetramethinemeromonomethine rhodacyanine dye with an absorption maximum of 655 nm (ethanol) and a molar absorption coefficient e=108 000 shows very promising photodependent biological activity. In general, the measured singlet oxygen quantum yield of the selected cyanines is low (
232 citations
TL;DR: It can be concluded that synthesized compounds exhibited better sedative-hypnotic and CNS depressant activities than anticonvulsant activity.
201 citations
TL;DR: One focus of this review is the effect macrominerals have on the acid-base status of the animal, and the attributes of organic or chelated minerals that might permit diet minerals to circumvent factors that inhibit absorption of more traditional inorganic forms of these minerals are discussed.
199 citations