Synthetic Double-Stranded RNAs Are Adjuvants for the Induction of T Helper 1 and Humoral Immune Responses to Human Papillomavirus in Rhesus Macaques
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...Synthetic analogs of dsRNA (i.e., Poly IC) have been used as adjuvants (Longhi et al., 2009; Stahl-Hennig et al., 2009; Trumpfheller et al., 2008) and can act through two distinct types of PRRs. Viral or synthetic dsRNA activates TLR3 in endosomes (Alexopoulou et al., 2001) or through cytosolic…...
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...Several synthetic analogs of dsRNA (Poly IC, Poly ICLC, and Poly IC12U) have been used as adjuvantswith soluble proteins, DC targeting constructs, or inactivated viral vaccines (Gowen et al., 2007; Stahl-Hennig et al., 2009; Trumpfheller et al., 2008)....
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...Furthermore, complexing Poly IC with poly-L-lysine and carboxymethylcellose (poly ICLC) prolongs the adjuvant effect in vivo (Levy et al., 1975; Stahl-Hennig et al., 2009)....
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...Among them, synthetic double-stranded RNA, polyinosinic:polycytidylic acid (poly IC), induces inflammation and long-lasting T cell immunity (Salem et al., 2006; Trumpfheller et al., 2008; Stahl-Hennig et al., 2009)....
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...Also, Stahl-Hennig et al. (2009) have shown that poly IC is a more potent adjuvant than other agonists for responses to protein antigens in rhesus macaques....
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"Synthetic Double-Stranded RNAs Are ..." refers background in this paper
...This may in part be due to the lack of TLR9 expression in myeloid primate DCs [15], which can be valuable for the priming of naı̈ve T cells and the induction of cellular immune responses [16,17]....
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6,758 citations
"Synthetic Double-Stranded RNAs Are ..." refers background in this paper
...This may in part be due to the lack of TLR9 expression in myeloid primate DCs [15], which can be valuable for the priming of naı̈ve T cells and the induction of cellular immune responses [16,17]....
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"Synthetic Double-Stranded RNAs Are ..." refers background in this paper
...MDA-5 is important for the IFN response induced by poly I:C [26,27]....
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