Journal ArticleDOI
Synthetic entries to 6-fluoro-7-substituted indole derivatives
Brian Mckittrick,Amedeo Arturo Failli,Robert John Steffan,Richard M. Soll,Philip F. Hughes,Jean Schmid,Andre A. Asselin,C. C. Shaw,R. Noureldin,G. Gavin +9 more
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TLDR
In this article, three synthetic entries of functionalized 6-fluoro-7-substituted indole derivatives were developed in connection with the preparation of 7-fluororo-8-substantituted-1,3,4,9-tetrahydropyrano[3, 4-b]indole-1-acetic acid derivatives.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-11-01. It has received 36 citations till now. The article focuses on the topics: Indole test.read more
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Antitumor benzothiazoles. 14. Synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles.
Ian Hutchinson,Mei-Sze Chua,Helen L. Browne,Valentina Trapani,Tracey D. Bradshaw,A. D. Westwell,Malcolm F. G. Stevens +6 more
TL;DR: The most potent broad spectrum agent in the NCI cell panel was 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (10h) which, unlike the 6-fluoro isomer (10d), produces no exportable metabolites in the presence of sensitive MCF-7 cells.
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Polyfluorinated ethanes as versatile fluorinated C2-building blocks for organic synthesis.
TL;DR: The chiral stationary phase for organic synthesis showed good chiral recognition ability towards various racemates including polymethine, chlorine, cadmium, and phosphorous.
Journal ArticleDOI
Fischer indole synthesis applied to the total synthesis of natural products
TL;DR: One of the oldest and most useful reactions in organic chemistry is the Fischer indole synthesis (FIS) as discussed by the authors, which is known to have a wide variety of applications including the synthesis of indole rings, often present as the framework in the total synthesis of natural products.
Journal ArticleDOI
A versatile synthetic methodology for the synthesis of tryptophols
TL;DR: The reduction reaction was found to proceed via an intermediate 1,3-diol-oxindole, which was obtained diastereoselectively and which was subsequently reduced to the corresponding tryptophol.
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The regiospecific synthesis of 5- and 7-monosubstituted and 5,6-disubstituted 2-arylbenzothiazoles†
TL;DR: In this article, the synthesis of 2-arylbenzothiazoles bearing both electron-withdrawing (-NO 2 ) and electron-donating (-NH 2 ) substituents on the aryl ring is described.
References
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Rapid chromatographic technique for preparative separations with moderate resolution
Abstract: (11) Potassium ferricyanide has previously been used to convert w'c-1,2-dicarboxylate groups to double bonds. See, for example, L. F. Fieser and M. J. Haddadln, J. Am. Chem. Soc., 86, 2392 (1964). The oxidative dldecarboxylation of 1,2-dlcarboxyllc acids is, of course, a well-known process. See Inter alia (a) C. A. Grob, M. Ohta, and A. Weiss, Helv. Chim. Acta, 41, 1911 (1958); and (b) E. N. Cain, R. Vukov, and S. Masamune, J. Chem. Soc. D, 98 (1969).
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Readily accessible 12-I-5 oxidant for the conversion of primary and secondary alcohols to aldehydes and ketones
D. B. Dess,J. C. Martin +1 more
TL;DR: Conversion de cyclohexanol, octanol, alcool benzylique and des alcools dimethoxy-and trimethoxy benzyliques par oxydation avec le triacetoxy-1, 1, 1 benzoiodoxole-1 2 one-3
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Methylenation of carbonyl compounds with ZnCH2Br2TiCl4. Application to gibberellins
TL;DR: A highly active species prepared from ZnCH2Br2TiCl4 reacted instantaneously with aldehydes and ketones to give methylenated products with exceptional selectivity.
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Reactions of allyltin compounds iii. allylation of aromatic halides with allyltributyltin in the presence of tetrakis(triphenylphosphine)palladium(o)
TL;DR: In this article, the reaction with aryl bromides with allyltributyltin in the presence of tetrakis(triphenylphosphine)palladium(O) was investigated.