Synthetic scale-up of a novel fluorescent probe and its biological evaluation for surface detection of Staphylococcus aureus.
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TLDR
The LGX fluorometric test for enzymatic MRSA/MSSA detection is reported on, highlighting the reasons rhodamines have been overlooked and also strategies to improve the synthesis of rhodamine-peptide conjugates.About:
This article is published in Molecular and Cellular Probes.The article was published on 2017-12-01 and is currently open access. It has received 2 citations till now.read more
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Ratiometric fluorescent probes for selective and sensitive visualization of bacterial microenvironment protease activity.
Qinghua Wang,Xiang Wang,Ying Sun,Xiaoxiao Yang,Xiaoxiao Yang,Leilei Zhang,Qingyang Zhang,Zhi-Qiang Hu,Hai-Yu Hu +8 more
TL;DR: The extracellular SspA protease of the human pathogen S. aureus is essential for evading the host immune defence system and two novel FRET probes for selective real-time ratiometric imaging of SSPA activity in live S.Aureus cells are reported.
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Synthesis and Spectral Properties of Novel Singapore Green Analogues for Protease Detection.
Luke Bywaters,Adam Le Gresley +1 more
TL;DR: Proof of concept that the use of Singapore Greens for protease probe generation is feasible via demonstration of proteolytic cleavage of one of the acylated analogues is obtained.
References
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Journal ArticleDOI
Synthesis and applications of Rhodamine derivatives as fluorescent probes
TL;DR: In this critical review the strategies for modification of Rhodamine dyes and a discussion on the variety of applications of these new derivatives as fluorescent probes are given.
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The true cost of antimicrobial resistance
Richard D. Smith,Joanna Coast +1 more
TL;DR: Richard Smith and Joanna Coast argue that current estimates of the cost of antibiotic resistance are misleading and may result in inadequate investment in tackling the problem.
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The reaction of vinyl grignard reagents with 2-substituted nitroarenes: A new approach to the synthesis of 7-substituted indoles
TL;DR: The reaction of three moles of vinylmagnesium bromide with one mole of nitroarene leads to the formation of indoles after aqueous work up of the mixture as mentioned in this paper.
Journal ArticleDOI
Combinatorial rosamine library and application to in vivo glutathione probe.
TL;DR: A highly selective library member toward reduced glutathione (GSH) was discovered, demonstrating the capability of in vivo GSH level sensing in live cells.