Systematic dissection of regulatory motifs in 2000 predicted human enhancers using a massively parallel reporter assay
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..., 2014) as well as high-throughput enhancer assays (Kheradpour et al., 2013), provide researchers with new tools to interrogate putative regulatory elements....
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...Genome targeting techniques, such as CRISPR-Cas9 (Gilbert et al., 2014) as well as high-throughput enhancer assays (Kheradpour et al., 2013), provide researchers with new tools to interrogate putative regulatory elements....
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Cites methods from "Systematic dissection of regulatory..."
...An analogous experimental approach that has recently been applied on a high throughput scale is using massively parallel reporter assays (16, 17)....
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"Systematic dissection of regulatory..." refers background in this paper
...(B) Predictive power for recognizing enhancers that are likely to show high wild-type reporter expression based on each of these individual features and a combination of features using logistic regression (Hall et al. 2009)....
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"Systematic dissection of regulatory..." refers background in this paper
...…recent studies that have used genome-wide chromatin maps to predict thousands of candi- date distal enhancer regions across multiple human cell types (Barski et al. 2007; Heintzman et al. 2009; Hesselberth et al. 2009; Ernst and Kellis 2010; Ernst et al. 2011), and we seek to characterize…...
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"Systematic dissection of regulatory..." refers background in this paper
...Genome-wide genetic association studies suggest that nearly 85% of disease-associated variants lie outside protein-coding regions (Hindorff et al. 2009), emphasizing the importance of a systematic understanding of regulatory elements in the human genome at the nucleotide level....
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...Genome-wide genetic association studies suggest that nearly 85% of disease-associated variants lie outside protein-coding regions (Hindorff et al. 2009), emphasizing the importance of a systematic understanding of regulatory elements in the human genome at the nucleotide level....
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2,646 citations