Journal ArticleDOI
Systems biology for complex diseases
Luonan Chen,Jiarui Wu +1 more
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TLDR
The aim of this special issue is to collect the latest advances in developing new computational and experimental approaches to decipher the complexity of diseases or on providing the implications and explanations for disease mechanisms and therapeutic endeavors in drug research, from systems biology perspective.Abstract:
Systems biology views a living organism as an interacting and dynamical network of genes, proteins, and biochemical reactions which give rise to the function and behavior of that organism, and is considered as a powerfully analytical approach to reveal the essential mechanisms of initiation and progression for complex diseases such as cancer, cardiovascular disease, and diabetes. The classical bio-medicine based on molecular biology, cell biology, genetics, and other experimental biology has made significant progress against diseases in general. However, the researchers on the biomedicine area still face the great challenge against the complex diseases, since the methodology of the classical experimental biology is mainly based on studying individual genes and proteins and treating organisms as simple and linear systems, which are not good enough to solve increasingly complicated problems of the diseases. Therefore, the methodologies and techniques of systems biology are strongly demanded for analyzing the molecular mechanisms of the complex diseases and providing new solutions to fight the complex diseases. The aim of this special issue is to collect the latest advances in developing new computational and experimental approaches to decipher the complexity of diseases or on providing the implications and explanations for disease mechanisms and therapeutic endeavors in drug research, from systems biology perspective. In this issue, there are two review papers, three research articles and two letters, which present recent research efforts in various aspects for understanding mechanisms of the complex diseases, including prostate cancer, ovarian cancer, liver cancer, diabetes, and neuronalread more
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Journal ArticleDOI
Computer-aided biomarker discovery for precision medicine: data resources, models and applications.
TL;DR: Deep insights are given into the advantages and challenges of current computational approaches for biomarker detection, and the future wisdom toward precision medicine and nation-wide healthcare are lighted up.
Journal ArticleDOI
Human Periosteal Derived Stem Cell Potential: The Impact of age
Concetta Ferretti,Guendalina Lucarini,Chiara Andreoni,Eleonora Salvolini,Novella Bianchi,Giovanni Vozzi,Antonio Gigante,Monica Mattioli-Belmonte +7 more
TL;DR: This is the first study taking on age-related changes in human periosteal precursor cells, and paving the way toward new regenerative medicine strategies in bone aging and/or bone metabolic diseases.
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Elucidating the crosstalk mechanism between IFN-gamma and IL-6 via mathematical modelling
Yun-feng Qi,Yanxin Huang,Hong-yan Wang,Yu Zhang,Yongli Bao,Luguo Sun,Yin Wu,Chun-Lei Yu,Zhenbo Song,Lihua Zheng,Ying Sun,Guannan Wang,Yuxin Li +12 more
TL;DR: A crosstalk model of the IFN-gamma and IL-6 pathways was developed that provided a good explanation of the experimental observations and provided insights that may inform further research to facilitate a better understanding of the cross-regulation mechanism between the two pathways.
Journal ArticleDOI
In vitro lifespan and senescent behaviour of human periosteal derived stem cells
Giovanni Vozzi,Guendalina Lucarini,Manuela Dicarlo,Chiara Andreoni,Eleonora Salvolini,Concetta Ferretti,Monica Mattioli-Belmonte +6 more
TL;DR: The findings suggest the possibility to use early-passage PDPCs for bone regenerative approaches based on the local recruitment of stem cells, whilst the later cell passages could be a suitable in vitro tool to validate scaffolds intended for bone regeneration in elderly subjects.
Journal ArticleDOI
Theoretical Studies on the Engagement of Interleukin 18 in the Immuno-Inflammatory Processes Underlying Atherosclerosis.
TL;DR: A model of the studied phenomenon, including selected pathways, based on the Petri-net theory, has been created and results showed that IL-18 is produced more often via caspase 1-independent pathway than caspases 1-dependent pathway, and it is found that this last pathway may be associated with caspasing 8 action.