T-Cell Exhaustion Signatures Vary with Tumor Type and Are Severe in Glioblastoma
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"T-Cell Exhaustion Signatures Vary w..." refers background in this paper
...Despite improvements in standard of care, median survival remains at just 15 to 17 months (1)....
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...Taken together, these findings suggest that exhaustion patterns among tumor-infiltrating T cells are (1) determined by tumor-intrinsic factors and not environment; (2) strongly influence infiltrating T-cell function; and (3) vary in severity across and reflect tumor type, with gliomas instigating particularly severe exhaustion....
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...Results:Our data reveal that GBM elicits a particularly severe T-cell exhaustion signature among infiltrating T cells characterized by: (1) prominent upregulation of multiple immune checkpoints; (2) stereotyped T-cell transcriptional programs matching classical virus-induced exhaustion; and (3) notable T-cell hyporesponsiveness in tumor-specific T cells....
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"T-Cell Exhaustion Signatures Vary w..." refers background in this paper
...Checkpoint blockade, as with all immunotherapies, encounters multiple challenges in GBM, including considerable intratumoral heterogeneity (2, 43, 44), poor immunogenicity (45, 46), low mutational burden (47), poor T-cell infiltration (48), and substantial tumor-elicited T-cell dysfunction (10)....
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