T-cell quality in memory and protection: implications for vaccine design
Citations
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Cites methods from "T-cell quality in memory and protec..."
...We then stimulated the four T cell subsets and expanded them in vitro for 7 d; we then measured production of IL-22, IL-17 and IFN-γ by multicolor intracellular staining and analyzed the data with Boolean gatin...
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743 citations
Cites background or methods from "T-cell quality in memory and protec..."
...For analysis of cytokine responses, we refer to the normalized distribution as the ‘‘quality’’ of the response (8)....
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...There is evidence that the pattern of production of these cytokines, termed ‘‘quality’’ (8), rather than the magnitude of the response, may be an important correlate of protection against pathogens (9–13)....
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719 citations
References
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"T-cell quality in memory and protec..." refers background in this paper
...The paradigm of segregating T cells into 'central memory' T cells (T CM cells) and 'effector memory' T cells (T EM cells), on the basis of their expression of CC-chemokine receptor 7 (CCR7) or CD62L, along with CD45R...
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2,894 citations
"T-cell quality in memory and protec..." refers background in this paper
...Also, chemokines such as CC-chemokine ligand 4 (CCL4; previously known as MIP-1β) may act as antagonists to HIV infectio...
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2,401 citations
"T-cell quality in memory and protec..." refers background in this paper
...In terms of effector function, IFNγ has been shown to have a role in the clearance of various bacterial, parasitic, viral or fungal infection...
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2,071 citations
"T-cell quality in memory and protec..." refers background in this paper
...As TLR7 and TLR8 are expressed by plasmacytoid DCs and myeloid DCs respectivel...
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