T cells selectively filter oscillatory signals on the minutes timescale.
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"T cells selectively filter oscillat..." refers background in this paper
...R interactions on the surface of eukaryotic cells initiate reversible signaling and transcriptional cascades that ultimately culminate in long-lasting or irreversible changes in gene expression and functional activation (1, 2)....
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3,027 citations
"T cells selectively filter oscillat..." refers background in this paper
...Part one of the optoCAR receptor was built by fusing the α-CD19 scFv (53) or the Lag17 αGFP nanobody (36) to the human CD8α hinge and transmembrane domains and the iLID light-sensitive domain (39) (SI Appendix, Fig....
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2,122 citations
"T cells selectively filter oscillat..." refers methods in this paper
...To construct light-responsive T cells, we engineered an optogenetically controlled chimeric antigen receptor (optoCAR) using a split receptor design similar to that of endogenous antigenic receptors, that is, the TCR/CD3 and B cell receptor (BCR) complexes, whose ligand-recognition and signaling domains are expressed as separate polypeptides (3)....
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1,710 citations
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