T1 Mapping for the Diagnosis of Acute Myocarditis Using CMR: Comparison to T2-Weighted and Late Gadolinium Enhanced Imaging
Vanessa M Ferreira,Stefan K. Piechnik,Erica Dall'Armellina,Theodoros D. Karamitsos,Jane M. Francis,Ntobeko A.B. Ntusi,Cameron J. Holloway,Robin P. Choudhury,Attila Kardos,Matthew D. Robson,Matthias G. Friedrich,Stefan Neubauer +11 more
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TLDR
Native T1 mapping as a novel criterion for the detection of acute myocarditis showed excellent and superior diagnostic performance compared with T2W-CMR.Abstract:
Objectives This study sought to test the diagnostic performance of native T1 mapping in acute myocarditis compared with cardiac magnetic resonance (CMR) techniques such as dark-blood T2-weighted (T2W)-CMR, bright-blood T2W-CMR, and late gadolinium enhancement (LGE) imaging. Background The diagnosis of acute myocarditis on CMR often requires multiple techniques, including T2W, early gadolinium enhancement, and LGE imaging. Novel techniques such as T1 mapping and bright-blood T2W-CMR are also sensitive to changes in free water content. We hypothesized that these techniques can serve as new and potentially superior diagnostic criteria for myocarditis. Methods We investigated 50 patients with suspected acute myocarditis (age 42 ± 16 years; 22% women) and 45 controls (age 42 ± 14 years; 22% women). CMR at 1.5-T (median 3 days from presentation) included: 1) dark-blood T2W-CMR (short-tau inversion recovery); 2) bright-blood T2W-CMR (acquisition for cardiac unified T2 edema); 3) native T1 mapping (shortened modified look-locker inversion recovery); and 4) LGE. Image analysis included: 1) global T2 signal intensity ratio of myocardium compared with skeletal muscle; 2) myocardial T1 relaxation times; and 3) areas of LGE. Results Compared with controls, patients had significantly higher global T2 signal intensity ratios by dark-blood T2W-CMR (1.73 ± 0.27 vs. 1.56 ± 0.15, p Conclusions Native T1 mapping as a novel criterion for the detection of acute myocarditis showed excellent and superior diagnostic performance compared with T2W-CMR. It also has a higher sensitivity compared with T2W and LGE techniques, which may be especially useful in detecting subtle focal disease and when gadolinium contrast imaging is not feasible.read more
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Journal ArticleDOI
Cardiovascular Magnetic Resonance in Nonischemic Myocardial Inflammation: Expert Recommendations.
Vanessa M Ferreira,Jeanette Schulz-Menger,Godtfred Holmvang,Christopher M. Kramer,Iacopo Carbone,Udo Sechtem,Ingrid Kindermann,Matthias Gutberlet,Leslie T. Cooper,Peter Liu,Matthias G. Friedrich +10 more
TL;DR: This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardian inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques.
Journal ArticleDOI
Clinical recommendations for cardiovascular magnetic resonance mapping of T1, T2, T2 and extracellular volume: A consensus statement by the Society for Cardiovascular Magnetic Resonance (SCMR) endorsed by the European Association for Cardiovascular Imaging (EACVI)
Daniel Messroghli,James C. Moon,Vanessa M Ferreira,Lars Grosse-Wortmann,Taigang He,Peter Kellman,Julia Mascherbauer,Reza Nezafat,Michael Salerno,Erik B. Schelbert,Andrew J. Taylor,Richard B. Thompson,Martin Ugander,Ruud B. van Heeswijk,Matthias G. Friedrich +14 more
TL;DR: This document provides a summary of the existing evidence for the clinical value of parametric mapping in the heart as of mid 2017, and gives recommendations for practical use in different clinical scenarios for scientists, clinicians, and CMR manufacturers.
Journal ArticleDOI
Myocardial T1 mapping and extracellular volume quantification: a Society for Cardiovascular Magnetic Resonance (SCMR) and CMR Working Group of the European Society of Cardiology consensus statement
James C. Moon,Daniel Messroghli,Peter Kellman,Stefan K. Piechnik,Matthew D. Robson,Martin Ugander,Peter D. Gatehouse,Andrew E. Arai,Matthias G. Friedrich,Stefan Neubauer,Jeanette Schulz-Menger,Jeanette Schulz-Menger,Erik B. Schelbert +12 more
TL;DR: This document provides recommendations for clinical and research T1 and ECV measurement, based on published evidence when available and expert consensus when not, and addresses controversies in the field.
Journal ArticleDOI
ESC Working Group Position Paper on Myocardial Infarction With Non-Obstructive Coronary Arteries
Stefan Agewall,John F. Beltrame,Harmony R. Reynolds,Alexander Niessner,Giuseppe M.C. Rosano,Alida L.P. Caforio,Raffaele De Caterina,Marco Zimarino,Marco Roffi,Keld Kjeldsen,Dan Atar,Juan Carlos Kaski,Udo Sechtem,Per Tornvall +13 more
TL;DR: Although DeWood's studies underscore the importance of obstructive CAD in AMI, it is fascinating that ∼10% had no significant CAD on coronary angiography, thereby eliciting an important set of questions—what is the mechanism of the myocardial damage in these patients?
Journal ArticleDOI
T1-mapping in the heart: accuracy and precision
Peter Kellman,Michael S. Hansen +1 more
TL;DR: The technical aspects of key T1-mapping methods and imaging protocols are described and their limitations including the factors that influence their accuracy, precision, and reproducibility are described.
References
More filters
Journal ArticleDOI
Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach.
TL;DR: A nonparametric approach to the analysis of areas under correlated ROC curves is presented, by using the theory on generalized U-statistics to generate an estimated covariance matrix.
Journal ArticleDOI
Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function.
Raymond J. Kim,David S. Fieno,Todd B. Parrish,Kathleen E. Harris,Enn-Ling Chen,Orlando P. Simonetti,Jeffrey M. Bundy,J. Paul Finn,Francis J. Klocke,Robert M. Judd +9 more
TL;DR: In the pathophysiologies investigated, contrast MRI distinguishes between reversible and irreversible ischemic injury independent of wall motion and infarct age.
Journal ArticleDOI
Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper
Matthias G. Friedrich,Udo Sechtem,Jeanette Schulz-Menger,Godtfred Holmvang,Pauline Alakija,Leslie T. Cooper,James A. White,Hassan Abdel-Aty,Matthias Gutberlet,Sanjay K Prasad,Anthony H. Aletras,Jean Pierre Laissy,Ian Paterson,Neil G. Filipchuk,Andreas Kumar,Matthias Pauschinger,Peter Liu +16 more
TL;DR: The International Consensus Group on CMR Diagnosis of Myocarditis was founded in 2006 to achieve consensus among CMR experts and develop recommendations on the current state-of-the-art use of CMR for myocarditis.
Journal ArticleDOI
Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy.
G M Felker,Richard E. Thompson,Joshua M. Hare,Ralph H. Hruban,D E Clemetson,David L. Howard,Kenneth L. Baughman,Edward K. Kasper +7 more
TL;DR: The underlying cause of heart failure has prognostic value in patients with unexplained cardiomyopathy and patients with peripartum cardiopathy appear to have a better prognosis than those with other forms of cardiomeopathy.
Journal ArticleDOI
Cardiovascular Magnetic Resonance Assessment of Human Myocarditis: A Comparison to Histology and Molecular Pathology
Heiko Mahrholdt,Christine Goedecke,Anja Wagner,Gabriel Meinhardt,Anasthasios Athanasiadis,Holger Vogelsberg,Peter Fritz,Karin Klingel,Reinhard Kandolf,Udo Sechtem +9 more
TL;DR: Contrast enhancement is a frequent finding in the clinical setting of suspected myocarditis and is associated with active inflammation defined by histopathology and is a valuable tool for the evaluation and monitoring of inflammatory heart disease.