Talins and kindlins: partners in integrin-mediated adhesion
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Cites background from "Talins and kindlins: partners in in..."
...The talin rod domain contains two additional F-actin–binding sites (ABS2 and ABS3), 11 vinculin-binding sites (VBSs), and binding sites for regulatory proteins, including RIAM (Rap1–GTP-interacting adapter molecule), Kank (KN motif and ankyrin repeat domains) family proteins (whose functions are discussed in the following paragraphs), and the Rho GTPase activating protein DLC1 (deleted in liver cancer 1; Calderwood et al., 2013; Sun et al., 2016)....
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...…including RIAM (Rap1–GTP-interacting adapter molecule), Kank (KN motif and ankyrin repeat domains) family proteins (whose functions are discussed in the following paragraphs), and the Rho GTPase activating protein DLC1 (deleted in liver cancer 1; Calderwood et al., 2013; Sun et al., 2016)....
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451 citations
Cites background from "Talins and kindlins: partners in in..."
...The protein products of ITGB1, CD151, and FERMT1 physically interact at the cell surface to mediate integrin signaling (Calderwood et al., 2013; Hemler, 2005)....
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References
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"Talins and kindlins: partners in in..." refers background in this paper
...RIAM and lamellipodin contain a RAS-associating domain (RA domain) and an adjacent pleckstrin homolog y domain (PH domain), and the structure of the RIAM RA–PH double domain suggests that they act as a proximity detector for activated RAP1A and PtdIns(4,5)P2 (REF....
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...The authors conclude that the major role of PtdInsP kinase Iγ in focal adhesions is to locally synthesize PtdIns(4,5)P2 that is required to orientate the talin head such that it can activate integrins77....
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...A similar phenotype was obtained with wildtype cells expressing a K274E mutation in the talin F2 FERM domain that inhibits PtdIns(4,5)P2binding and dramatically reduces integrin activation37....
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...PtdIns(4,5)P2 has been shown to relieve the F3–R9 interaction62 and could therefore activate talin....
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...76); RIAM and therefore talin are only recruited to RAP1A•GTP embedded in PtdIns(4,5)P2-rich microdomains....
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