Tandem Strecker/C(sp3)–H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH4SCN as a cyanating agent
21 Sep 2021-Organic chemistry frontiers (The Royal Society of Chemistry)-Vol. 8, Iss: 22, pp 6384-6389
TL;DR: An I2O5-mediated multicomponent reaction that allows the single-step construction of cyano-functionalized imidazo[1,5-a]pyridines with molecular diversity was realized for the first time.
Abstract: An I2O5 promoted tandem Strecker/C(sp3)–H amination reaction of pyridine-2-carboxaldehydes, benzylamines and NH4SCN has been reported. This multicomponent reaction that allows the single-step construction of biologically important cyano-functionalized imidazo[1,5-a]pyridines with molecular diversity was realized for the first time. Moreover, the use of safe and easy-to-handle NH4SCN as a surrogate cyanating agent makes this protocol appealing for potential applications.
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