Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease
Citations
4,026 citations
3,589 citations
Cites background from "Targeted Disruption of the Mouse St..."
...This is supported by the Stat1 KO mouse, which displays loss of only IFN signaling, despite multiple reports of Stat1 activation in response to a range of other cytokines in vitro [106, 151]....
[...]
...This susceptibility has been attributed to defective immune system function as a result of the combined loss of types I and II IFN responses [151]....
[...]
2,956 citations
2,720 citations
2,673 citations
References
10,800 citations
"Targeted Disruption of the Mouse St..." refers methods in this paper
...Cytoplasmic and nuclear extracts were prepared from cells as Fujita, T., Sakakibara, J., Sudo, Y., Miyamoto, M., Kimura, Y., and previously described (Dignam et al., 1983)....
[...]
5,746 citations
2,654 citations
"Targeted Disruption of the Mouse St..." refers methods in this paper
..., 1995); however, they also show distinct Cell Culture and Protein Extracts patterns of binding to natural enhancer elements, possiMouse embryo fibroblasts were prepared from individual 12–13 day bly explaining an inability of STAT3 to substitute for embryos by standard methods (Todaro and Green, 1963) and were STAT1 in mutant animals....
[...]
...…Cell Culture and Protein Extractspatterns of binding to natural enhancer elements, possiMouse embryo fibroblasts were prepared from individual 12–13 day bly explaining an inability of STAT3 to substitute for embryos by standard methods (Todaro and Green, 1963) and were STAT1 in mutant animals....
[...]
2,438 citations
"Targeted Disruption of the Mouse St..." refers background in this paper
...…infections and the requirement of IFNg receptors for resistance to vaccinia capable of binding and activating the enhancer of the IRF-1 gene (Pine et al., 1994; Sims et al., 1993; Lamb etvirus infection (Huang et al., 1993; Müller et al., 1994; Schijns et al., 1994; Steinhoff et al., 1995)....
[...]
1,878 citations
"Targeted Disruption of the Mouse St..." refers background or methods in this paper
...cate to the nucleus, where they recognize discrete cisChemically mutagenized human fibrosarcoma cells acting regulatory sequences in DNA (for reviews see defective in STAT1 have been isolated and used to demDarnell et al., 1994; Schindler and Darnell, 1995; Levy, onstrate the requirement for STAT1 in IFN responses 1995)....
[...]
...…they recognize discrete cis- Chemically mutagenized human fibrosarcoma cells acting regulatory sequences in DNA (for reviews see defective in STAT1 have been isolated and used to demDarnell et al., 1994; Schindler and Darnell, 1995; Levy, onstrate the requirement for STAT1 in IFN responses 1995)....
[...]
...Functional redundancy could be provided by STAT3, a closely related protein phosphorylated by RNA Isolation and Analysis many of the same cytokines that activate STAT1, includTotal RNA was isolated from cells disrupted in guanidinium isothioing LIF, IL-6, CSF-1, PDGF, and EGF, as well as IFN cyanate by centrifugation through CsCl, fractionated on formalde(Schindler and Darnell, 1995)....
[...]
...…by RNA Isolation and Analysis many of the same cytokines that activate STAT1, includ- Total RNA was isolated from cells disrupted in guanidinium isothioing LIF, IL-6, CSF-1, PDGF, and EGF, as well as IFN cyanate by centrifugation through CsCl, fractionated on formalde(Schindler and Darnell, 1995)....
[...]