Targeting autophagy enhances sorafenib lethality for hepatocellular carcinoma via ER stress-related apoptosis.
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Cites background from "Targeting autophagy enhances sorafe..."
..., 2006), and this pathway facilitates sorafenib resistance in hepatocellular carcinoma cell lines (Shi et al., 2011)....
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...Like PERK, IRE1a-JNK signaling can sustain autophagy (Ogata et al., 2006), and this pathway facilitates sorafenib resistance in hepatocellular carcinoma cell lines (Shi et al., 2011)....
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References
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"Targeting autophagy enhances sorafe..." refers background in this paper
...Hepatocellular carcinoma (HCC) is the third cause of cancerrelated death globally, and the majority of patients with HCC die within one year of diagnosis.(1) Recently, sorafenib, a multikinase inhibitor of Raf/MEK/ERK signaling and the receptor tyrosine kinase, was shown to induce apoptosis and inhibit tumor proliferation as well as angiogenesis in a variety of tumors....
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3,749 citations
"Targeting autophagy enhances sorafe..." refers background in this paper
...Recently, sorafenib, a multikinase inhibitor of Raf/MEK/ERK signaling and the receptor tyrosine kinase, was shown to induce apoptosis and inhibit tumor proliferation as well as angiogenesis in a variety of tumors.(2,3) The molecular involvement of the Raf-1 and tyrosine kinase signaling pathways has been well established in the pathogenesis of HCC and provides a rationale for the investigation of sorafenib in HCC treatment....
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3,684 citations
"Targeting autophagy enhances sorafe..." refers background in this paper
...1168 Autophagy Volume 7 issue 10 pronounced cell toxicity, as exemplified by severe neurodegeneration in Atg5 and Atg7 mice.(33,34) Our data also demonstrated that inhibition of autophagic degradation resulted in ER stress potentiation....
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3,398 citations
"Targeting autophagy enhances sorafe..." refers background in this paper
...Unlike proteasomal degradation, the autophagic breakdown of substrates is not limited by steric considerations; therefore, autophagy can sequester and degrade entire organelles.(12) A number of anti-neoplastic therapies have been observed to induce autophagy in cancer cells....
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3,349 citations
"Targeting autophagy enhances sorafe..." refers background in this paper
...1168 Autophagy Volume 7 issue 10 pronounced cell toxicity, as exemplified by severe neurodegeneration in Atg5 and Atg7 mice.(33,34) Our data also demonstrated that inhibition of autophagic degradation resulted in ER stress potentiation....
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