Targeting calcium signaling in cancer therapy.
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...iP3Rs in Cancer IP3Rs control different hallmarks of cancer (97, 98)....
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"Targeting calcium signaling in canc..." refers background in this paper
...com/locate/apsb Acta Pharmaceutica Sinica B Acta Pharmaceutica Sinica B 2017;7(1):3–17...
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...The intracellular Ca2þ homeostasis is governed by a network composed of various Ca2þ channels and transporters: (1) IP3R or ryanodine receptor (RyR) mediating Ca2þ release from endoplasmic/ sarcoplasmic reticulum (ER/SR); (2) Ca2þ-ATPase pumping Ca2þ from cytosol back to ER/SR or extracellular space; (3) Ca2þ channels or transporters allowing Ca2þ influx across plasma membrane (PM) from extracellular Ca2þ reservoir, such as voltage-gated Ca2þ channel (VGCC), transient receptor potential channel (TRP), Ca2þ releaseactivated Ca2þ channel (CRAC), Naþ/Ca2þ exchanger (NCX) and purinergic receptor; (4) mitochondrial Ca2þ uniporter (MCU) regulating mitochondrial Ca2þ uptakes (Fig....
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...proteins: (1) IP3Rs mediating Ca 2þ release from endoplasmic reticulum (ER); (2) Ca2þ-ATPases pumping Ca2þ from cytosol to the ER or to extracellular space; (3) plasma membrane Ca2þ channels or...
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...copyranosyl-20(S)-protopanaxadiol; CaM, calmodulin; CaMKII, calmodulin-dependent protein kinase II; CBD, sazepine; CRAC, Ca2þ release-activated Ca2þ channel; CTL, cytotoxic T cells; CYP3A4, cytochrome P450 3A4; m; HCX, Hþ/Ca2þ exchangers; IP3, inositol 1,4,5-trisphosphate; IP3R (1, 2, 3), IP3 receptor (type 1, type 2, type ochondrial Ca2þ uniporter; MCUR1, MCU uniporter regulator 1; MICU (1, 2, 3), mitochondrial calcium uptake ght-chain kinase; NCX, Naþ/Ca2þ exchanger; NFAT, nuclear factor of activated T cells; NF-κB, nuclear factorOSCC, oral squamous cell carcinoma cells; PKC, protein kinase C; PM, plasma membrane; PMCA, plasma y transition pore; ROS, reactive oxygen species; RyR, ryanodine receptor; SERCA, SR/ER Ca2þ-ATPase; SOCE, y pathway Ca2þ-ATPase; TEA, tetraethylammonium; TG, thapsigargin; TPC2, two-pore channel 2; TRIM, 1-(2P (A, C, M, ML, N, P, V), transient receptor potential (ankyrin, canonical, melastatin, mucolipin, no anilloid); VGCC, voltage-gated Ca2þ channel ursing and Health Innovation, The University of Texas at Arlington, LS Building 239, 501 S....
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