Targeting eosinophils in allergy, inflammation and beyond
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TLDR
Recent advances in the development of first-generation eosinophil-targeted therapies are described and strategies for using personalized medicine to treat eOSinophilic disorders are highlighted.Abstract:
Eosinophils can regulate local immune and inflammatory responses, and their accumulation in the blood and tissue is associated with several inflammatory and infectious diseases. Thus, therapies that target eosinophils may help control diverse diseases, including atopic disorders such as asthma and allergy, as well as diseases that are not primarily associated with eosinophils, such as autoimmunity and malignancy. Eosinophil-targeted therapeutic agents that are aimed at blocking specific steps involved in eosinophil development, migration and activation have recently entered clinical testing and have produced encouraging results and insights into the role of eosinophils. In this Review, we describe recent advances in the development of first-generation eosinophil-targeted therapies and highlight strategies for using personalized medicine to treat eosinophilic disorders.read more
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Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma
Mario Castro,Jonathan Corren,Ian D. Pavord,Jorge Maspero,Sally E. Wenzel,Klaus F. Rabe,William W. Busse,Linda B. Ford,Lawrence Sher,J. Mark FitzGerald,Constance H. Katelaris,Yuji Tohda,Bingzhi Zhang,Heribert Staudinger,Gianluca Pirozzi,Nikhil Amin,Marcella Ruddy,Bolanle Akinlade,Asif Khan,Jingdong Chao,Renata Martincova,Neil M.H. Graham,Jennifer D. Hamilton,Brian N. Swanson,Neil Stahl,George D. Yancopoulos,Ariel Teper +26 more
TL;DR: Patients who received dupilumab had significantly lower rates of severe asthma exacerbation than those who received placebo, as well as better lung function and asthma control.
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Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma.
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TL;DR: In patients with glucocorticoid‐dependent severe asthma, dupilumab treatment reduced oral glucoc Corticoid use while decreasing the rate of severe exacerbations and increasing the FEV1.
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Severe eosinophilic asthma treated with mepolizumab stratified by baseline eosinophil thresholds: a secondary analysis of the DREAM and MENSA studies.
Hector Ortega,Steven W. Yancey,Bhabita Mayer,Necdet B Gunsoy,Oliver N. Keene,Eugene R. Bleecker,Christopher E. Brightling,Ian D. Pavord +7 more
TL;DR: An analysis of data from two randomised, double-blind, placebo-controlled studies of at least 32 weeks duration has shown a close relationship between baseline blood eosinophil count and clinical efficacy of mepolizumab in patients with severe eOSinophilic asthma and a history of exacerbations.
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Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.
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