Targeting Free Radicals in Oxidative Stress-Related Human Diseases.
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...It has been known that overproduction of free radicals, such as reactive oxygen species (ROS), plays an important part in the development of many chronic diseases [17]....
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...The most effective free radicals are derived from molecular oxygen, such as superoxide anion (O2 ), hydrogen peroxide (H2O2), peroxyl radical (ROO⋅) and the very reactive hydroxyl radical (⋅OH), which are termed reactive oxygen species (ROS), and these substances are generally considered to be toxic to cells [1,2]....
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"Targeting Free Radicals in Oxidativ..." refers background in this paper
...Oxidative Stress and AD The pathogenesis of AD is linked to the accumulation of the neurotoxic b-amyloid peptide (Ab) which is capable of forming amyloid plaques [56]....
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"Targeting Free Radicals in Oxidativ..." refers background in this paper
...may generate free radicals via their catalytic decomposition of hydrogen peroxide (Fenton reaction) [5] (Figure 2)....
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...ROS and RNS are known to play dual roles as species that may be either deleterious or beneficial in living systems [5]....
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...Among the most important ROS are the hydroxyl radical ( OH), the superoxide radical anion (O2 [551_TD$DIFF]), nitric oxide (NO ), and peroxyl radicals (ROO ) [4], as well as non-radical species such as hydrogen peroxide (H2O2), singlet oxygen ( (1)O2), hypochlorous acid (HOCl), and peroxynitrite (ONOO ) [5] (Figure 1)....
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...A sustained and delicate balance between the beneficial and harmful effects of ROS/RNS is an important aspect of healthy organisms, and is achieved by a collection of mechanisms that are described as ‘redox regulation' [5]....
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"Targeting Free Radicals in Oxidativ..." refers background in this paper
...However, it has been shown more recently that targeting the vital mechanisms which maintain the survival of cancer cells is a promising approach for cancer therapy [11]....
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