Targeting hypoxia in cancer therapy
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Cites background from "Targeting hypoxia in cancer therapy..."
...Radiation and drug resistance Resistance of cancer cells to treatment-induced apoptosis is one of the biggest obstacles in cancer therapy.(92) A vast number of cancer patients relapse and suffer from recurring tumors as a result of micro-residual disease, the resistant subpopulation of cancer cells, leading to local recurrence and/or metastasis....
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Cites background from "Targeting hypoxia in cancer therapy..."
...Palazón et al., 2012; Semenza, 2014; Wilson and Hay, 2011)....
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...…to radiotherapy, chemotherapy, and immunotherapy (e.g., fewer oxygen radicals and cell cycle arrest) (Huang et al., 2013; Neri and Supuran, 2011; Wilson and Hay, 2011); tumor growth and genomic instability and expression of growth factors (e.g., IGF1 and TGF-a), oncogenes, and tumor…...
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...In addition to protection from the immune system, hypoxia may select for more malignant cells because cells that respond to physiological cues normally undergo apoptosis under hypoxic conditions (Wilson and Hay, 2011)....
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...Collectively, these observations may explain why intratumoral hypoxia correlates with a poor prognosis in many human cancers (Wilson and Hay, 2011)....
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...Hypoxia also provides a niche for so-called cancer stem cells and facilitates inflammation while also conferring resistance to radiation and many widely used therapeutic agents (Wilson and Hay, 2011)....
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