Targeting the Thioredoxin System for Cancer Therapy.
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...Other H2O2 scavengers include catalase, which is mainly located in the peroxisomes where it converts H2O2 to water and oxygen [103], and the peroxiredoxin (PRX) system [104], relying upon the thioredoxin (TRX) and thioredoxin reductase catalytic cycle [105,106]....
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...thioredoxin reductase catalytic cycle [105,106]....
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"Targeting the Thioredoxin System fo..." refers background in this paper
...Rationale for Targeting TrxR/Trx in Cancer Hanahan and Weinberg described the hallmarks of cancer in their classic article [40], suggesting that at least several essential alterations must take place for tumor development, such as...
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...The elevated ROS content is essential for maintaining tumor phenotypes, but also renders cancer cells vulnerable to oxidative stress [5]....
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...This high ROS content also renders cancer cells more sensitive to ROS than non-malignant cells, which sets the tone for the ROS-mediated cancer therapy [5,6,8,11,54]....
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"Targeting the Thioredoxin System fo..." refers background in this paper
...The antioxidant function of the Trx system is beneficial for cancer cell survival because cancer cells usually harbor increased level of ROS compared to normal cells [52,53]....
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