Targeting TRK family proteins in cancer.
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...Different components in the cascade are highly variable in human cancers (24)....
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...Activation of the ERK cascade occurs in most cancer types, whereby activating mutations of this pathway are the most abundant oncogenic factor across all cancer types (24)....
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"Targeting TRK family proteins in ca..." refers background in this paper
...In turn, this triggers TRK kinase activation that induces cell proliferation, differentiation, apoptosis, and survival of neurons and other cells types where this signaling may be activated via the downstream PI3K, RAS/MAPK/ERK and phospholipase C-gamma (PLC-g) signaling transduction pathways (Kaplan et al., 1991; Kawamura et al., 2007, 2009, 2011; Klein, Jing, Nanduri, O'Rourke, & Barbacid, 1991; Loeb, Stephens, Copeland, Kaplan, & Greene, 1994)....
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...…types where this signaling may be activated via the downstream PI3K, RAS/MAPK/ERK and phospholipase C-gamma (PLC-g) signaling transduction pathways (Kaplan et al., 1991; Kawamura et al., 2007, 2009, 2011; Klein, Jing, Nanduri, O'Rourke, & Barbacid, 1991; Loeb, Stephens, Copeland, Kaplan, & Greene,…...
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"Targeting TRK family proteins in ca..." refers background in this paper
...…as these inhibitors undergo clinical testing in the pediatric population whose nervous system would not complete its development until well into the adolescence, a population that has one of the highest rates of depression and suicide (Devenish, Berk, & Lewis, 2016; Tau & Peterson, 2010)....
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"Targeting TRK family proteins in ca..." refers background in this paper
...For example, in pediatric patients with diffuse intrinsic pontine glioma (DIPG) andpediatric non-brainstemglioblastoma,NTRK gene fusions account for up to 47% of driver events (Wu et al., 2014)....
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