Journal ArticleDOI
Telomeres in Cancer: Length, Positioning and Epigenetics
Trupti Patel,Sulekha R Nair,Lekshmi Mohan,Fahmina Y,Ashwini,Devi S,VA Saimadhukiran Dabbiru +6 more
- Vol. 2016, Iss: 01, pp 1-7
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TLDR
An account of how telomere shortening, lengthening, positioning in the nucleus and its associated epigenetic modifications set cancer cells apart from normal cells is given.Abstract:
Telomeres, the tandem nucleotide sequences at the termini of the DNA, enables the masking of DNA from repair mechanisms, thus protecting them from being considered as double stranded breaks. When the maintenance of telomeres goes awry, several diseases including cancer are resulted. Here in this review, we give an account of how telomere shortening, lengthening, positioning in the nucleus and its associated epigenetic modifications set cancer cells apart from normal cells.read more
Citations
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Advancement in Genomics: A Review
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Using Metformin for Cancer Prevention/Treatment
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Prospective Review on Genetic Disorders
Maddula K,Juluru A +1 more
TL;DR: A genetic disorder is a genetic condition which is a result of one or more abnormalities in the genome, which is mostly observed from birth (congenital) and generally depends on environmental factors and events in his development.