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TLDR: If one area manifests clinically, it can be removed by Mohs surgery, but the second, noncontiguous, area may not be found during treatment, only to appear later and be considered a recurrence of theMohs surgery.

Abstract: If one area manifests clinically, it can be removed by Mohs surgery, but the second, noncontiguous, area may not be found during treatment, only to appear later and be considered a recurrence of the Mohs surgery. Second, human error accounts for a 5-year 99% cure rate for primary basal cell carcinomas by Mohs technique compared with the theoretically predicted 100% cure rate. With the numerous and detailed steps for excision, orientation, mapping, preparing frozen sections, and histologic interpretation of the tissue, errors are possible and may result in a recurrence. For example, if the tissue is mislabeled or mapped improperly and persistent tumor is noted microscopically, the wrong area of the wound may be reexcised. In addition, the frozen section may contain gaps or may not include the entire surface and a false-negative interpretation made, resulting in a recurrence. Fortunately, the technique includes careful routines to minimize the chance of human error.