Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke
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Cites background or result from "Temporal and Spatial Dynamics of Ce..."
...[47] demonstrate that DCs are increased by 20-fold on Day 3 and 12-fold on Day 7 and thus, constituted a substantial proportion of infiltrating cells....
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...However, an interesting observation is that the infiltration of other inflammatory cells, including macrophages, lymphocytes, and DCs, in the ischemic hemisphere precedes the neutrophilic influx [47]....
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...In a mouse transient MCAO model, flow cytometric analysis of cell samples isolated from the ischemic brains shows that the majority of leukocyte cells in the ischemic hemisphere at 3 days after MCAO includes neutrophils [47], which is consistent with most reports in the literature [43, 48, 49]....
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...A recent study seems to challenge the current view, as it provides evidence demonstrating that the recruitment of other inflammatory cells may precede neutrophil infiltration in response to cerebral ischemia [47]....
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...It occurs 4 hours after stroke and reaches maximum infiltration in 7 days [56]....
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