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Journal ArticleDOI

Tendon injury and tendinopathy: healing and repair.

Pankaj Sharma, +1 more
- 01 Jan 2005 - 
- Vol. 87, Iss: 1, pp 187-202
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TLDR
There is limited and mixed high-level evidence to support the, albeit common, clinical use of these modalities and further research and scientific evaluation are required before biological solutions become realistic options.
Abstract
Tendon disorders are frequent and are responsible for substantial morbidity both in sports and in the workplace. Tendinopathy, as opposed to tendinitis or tendinosis, is the best generic descriptive term for the clinical conditions in and around tendons arising from overuse. Tendinopathy is a difficult problem requiring lengthy management, and patients often respond poorly to treatment. Preexisting degeneration has been implicated as a risk factor for acute tendon rupture. Several physical modalities have been developed to treat tendinopathy. There is limited and mixed high-level evidence to support the, albeit common, clinical use of these modalities. Further research and scientific evaluation are required before biological solutions become realistic options.

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Citations
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References
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Journal ArticleDOI

Vascular endothelial growth factor (VEGF) and its receptors

TL;DR: Recent developments that have widened considerably the understanding of the mechanisms that control V EGF production and VEGF signal transduction are focused on and recent studies that have shed light on the mechanisms by which VEGf regulates angiogenesis are reviewed.
Journal ArticleDOI

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.

TL;DR: The results suggest that the physiologic role of PPAR gamma 2 is to regulate development of the adipose lineage in response to endogenous lipid activators and that this factor may serve to link the process of adipocyte differentiation to systemic lipid metabolism.
Journal ArticleDOI

Calcitonin gene-related peptide is a potent vasodilator

TL;DR: It is suggested that local extravascular release of CGRP may be involved in the physiological control of blood flow and that circulating C GRP may contribute to hyperaemia in certain pathological conditions.
Book Chapter

A Quantitative Analysis

Journal ArticleDOI

Histopathological changes preceding spontaneous rupture of a tendon. A controlled study of 891 patients

TL;DR: Findings clearly indicate that, at least in an urban population, degenerative changes are common in the tendons of people who are older than thirty-five years and that these changes are associated with spontaneous rupture.
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