Testicular seminoma and non-seminoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
Jan Oldenburg,Sophie D. Fosså,Janine Nuver,Axel Heidenreich,H.-J. Schmoll,Carsten Bokemeyer,Alan Horwich,Jörg Beyer,V. Kataja +8 more
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TLDR
This work presents the results of a randomised, double-blind, placebo-controlled trial of 12 patients at the University Hospital of Hamburg with a history of Oncology, Haematology, and Bone Marrow Transplantation with Section Pneumology using a single donor for Haemostaseology.About:
This article is published in Annals of Oncology.The article was published on 2013-10-01 and is currently open access. It has received 229 citations till now. The article focuses on the topics: Seminoma.read more
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Testicular germ cell tumours
Ewa Rajpert-De Meyts,Katherine A. McGlynn,Keisei Okamoto,Michael A.S. Jewett,Carsten Bokemeyer +4 more
TL;DR: The consensus on how to treat testicular germ cell tumours is summarised, a few controversies and improvements in the understanding of late effects of treatment and quality of life for survivors are focused on.
Journal ArticleDOI
Testicular Cancer — Discoveries and Updates
TL;DR: The treatment of testicular cancer is a success story in oncology, and emphasis is shifting toward maintaining high cure rates and reducing or effectively managing late effects of treatment.
Journal ArticleDOI
ESMO Consensus Conference on testicular germ cell cancer: diagnosis, treatment and follow-up
Friedemann Honecker,Jorge Aparicio,Daniel M. Berney,Jörg Beyer,Carsten Bokemeyer,Richard Cathomas,Noel W. Clarke,Gabriella Cohn-Cedermark,Gedske Daugaard,K-P Dieckmann,Karim Fizazi,Sophie D. Fosså,J R Germa-Lluch,Patrizia Giannatempo,Jourik A. Gietema,Silke Gillessen,Silke Gillessen,Hege Sagstuen Haugnes,Axel Heidenreich,Kari Hemminki,Robert Huddart,Michael A.S. Jewett,Florence Joly,Jakob Lauritsen,Anja Lorch,Andrea Necchi,Nicola Nicolai,Christoph Oing,Jan Oldenburg,D. Ondruš,Alexandros Papachristofilou,Thomas Powles,Aslam Sohaib,Olof Ståhl,T. Tandstad,Guy C. Toner,Alan Horwich +36 more
TL;DR: The aim of the conference was to develop detailed recommendations on topics relating to testicular cancer that are not covered in detail in the current ESMO Clinical Practice Guidelines (CPGs) and where the available level of evidence is insufficient.
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A Nationwide Cohort Study of Stage I Seminoma Patients Followed on a Surveillance Program
Mette Saksø Mortensen,Jakob Lauritsen,Maria Gry Gundgaard,Mads Agerbæk,Niels V. Holm,Ib Jarle Christensen,Hans von der Maase,Gedske Daugaard +7 more
TL;DR: In the world's largest study of stage I seminoma patients, surveillance was found to be a safe alternative to adjuvant therapies and tumor size was a significant factor for relapse.
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The genomic landscape of testicular germ cell tumours: from susceptibility to treatment
TL;DR: Understanding of the genomic basis of TGCT offers a clear opportunity for clinical benefit in terms of preventing invasive cancer arising in young men, decreasing the burden of chemotherapy-related survivorship issues and reducing mortality in the minority of patients who have treatment-refractory disease.
References
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International germ cell consensus classification: A prognostic factor-erased staging system for metastatic germ cell cancers
Graham M. Mead,S. P. Stenning,P. A. Cook,Sophie D. Fosså,Alan Horwich,Stan B. Kaye,R.T.D. Oliver,Phm deMulder,R deWit,Gerrit Stoter,Richard Sylvester,Dean F. Bajorin,George J. Bosl,M Mazumdar,Craig R. Nichols,Robert J. Amato,Giorgio Pizzocaro,Jean-Pierre Droz,Andrew Kramar,Gedske Daugaard,H. Cortes-Funes,Luis Paz-Ares,John A. Levi,B. M. Colls,V J Harvey,C Coppin +25 more
TL;DR: An easily applicable, clinically based, prognostic classification for GCT has been agreed on between all the major clinical trial groups who are presently active worldwide and should be used in clinical practice and in the design and reporting of clinical trials to aid international collaboration and understanding.
Journal ArticleDOI
Radiotherapy versus single-dose carboplatin in adjuvant treatment of stage I seminoma: a randomised trial
R.T.D. Oliver,Mason,Graham M. Mead,H. von der Maase,Gordon J. S. Rustin,Johnathan Joffe,R. de Wit,Nina Aass,John Graham,Robert E. Coleman,S.J. Kirk,Sally P. Stenning +11 more
TL;DR: This trial has shown the non-inferiority of carboplatin to radiotherapy in the treatment of stage I seminoma, although the absence of disease-related deaths and preliminary data indicating fewer second primary testicular germ-cell tumours favourcarboplatin use, these findings need to be confirmed beyond 4 years' follow-up.
Journal ArticleDOI
Medical Treatment of Advanced Testicular Cancer
TL;DR: Clinical trials have led to evidence-based treatment recommendations for advanced testicular cancer based on risk stratification, and clinicians should be familiar with the potential complications of these therapies.
Journal ArticleDOI
Organ sparing surgery for malignant germ cell tumor of the testis
TL;DR: After a long-term followup of greater than 7 years organ sparing surgery represents a viable therapeutic approach to bilateral testicular germ cell tumor with an excellent postoperative outcome.
Related Papers (5)
International germ cell consensus classification: A prognostic factor-erased staging system for metastatic germ cell cancers
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Maintaining success, reducing treatment burden, focusing on survivorship: highlights from the third European consensus conference on diagnosis and treatment of germ-cell cancer
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International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers. International Germ Cell Cancer Collaborative Group.
Peter M Wilkinson,G Read +1 more