Tet-Mediated Formation of 5-Carboxylcytosine and Its Excision by TDG in Mammalian DNA
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Cites background from "Tet-Mediated Formation of 5-Carboxy..."
...…all the mentioned mechanisms of active DNA demethylation, the BER pathway uses thymine DNA glycosylase (TDG) to cleave off the modified residueF thymine, 5-hydroxymethyl-uracil, 5-formyl-cytosine, and 5-carboxy-cytosineFand replace it with a naked cytosine (Cortellino et al, 2011; He et al, 2011)....
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Cites background from "Tet-Mediated Formation of 5-Carboxy..."
...The recent discoveries of demethylases that actively remove methylations in DNA and histones provide a dynamic picture of mammalian gene expression regulation through reversible methylation (He et al., 2011; Ito et al., 2011; Shi et al., 2004; Tahiliani et al., 2009; Tsukada et al., 2006)....
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References
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