Textbook of biochemistry with clinical correlations
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This beautifully illustrated and well-written book, with an impressive array of authors, is aimed at both undergraduate and postgraduate level and emphasises the biochemistry of mammalian cells.Abstract:
Textbook of biochemistry with clinical correlations , 4th edn TM Devlin, ed pp xvii + 1186, illustrated Wiley-Liss, New York, 1997 £2995, hardback
This beautifully illustrated and well-written book, with an impressive array of authors, is aimed at both undergraduate and postgraduate level As the editor states in the preface, it is not intended to be a compendium of biochemistry but rather emphasises the biochemistry of mammalian cells The first 22 chapters cover …read more
Citations
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Journal ArticleDOI
The Definition of Primary and Secondary Glioblastoma
Hiroko Ohgaki,Paul Kleihues +1 more
TL;DR: IDH1 mutations are the earliest detectable genetic alteration in precursor low-grade diffuse astrocytomas and in oligodendrogliomas, indicating that these tumors are derived from neural precursor cells that differ from those of primary glioblastomas.
Journal ArticleDOI
Pharmaco-metabonomic phenotyping and personalized drug treatment.
T. Andrew Clayton,John C. Lindon,Olivier Cloarec,Henrik Antti,Claude Charuel,Gilles Hanton,Jean-Pierre Provost,Jean-Loic Le Net,David Baker,Rosalind Walley,Jeremy R. Everett,Jeremy K. Nicholson +11 more
TL;DR: An alternative and conceptually new ‘pharmaco-metabonomic’ approach to personalizing drug treatment is described, which uses a combination of pre-dose metabolite profiling and chemometrics to model and predict the responses of individual subjects.
Journal ArticleDOI
IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas
TL;DR: IDH1 mutations are a strong predictor of a more favorable prognosis and a highly selective molecular marker of secondary glioblastomas that complements clinical criteria for distinguishing them from primary gliOBlastomas.
Journal Article
FK866, a Highly Specific Noncompetitive Inhibitor of Nicotinamide Phosphoribosyltransferase, Represents a Novel Mechanism for Induction of Tumor Cell Apoptosis
Max Hasmann,Isabel Schemainda +1 more
TL;DR: This work has identified the first low molecular weight compound, designated FK866, which induces apoptosis by highly specific, noncompetitive inhibition of nicotinamide phosphoribosyltransferase (NAPRT), a key enzyme in the regulation of NAD+ biosynthesis from the natural precursor Nicotinamide.
Journal ArticleDOI
Genetic alterations and signaling pathways in the evolution of gliomas
Hiroko Ohgaki,Paul Kleihues +1 more
TL;DR: The current status of genetic alterations and signaling pathways operative in the evolution of astrocytic and oligodendroglial tumors is summarized.
References
More filters
Journal ArticleDOI
The Definition of Primary and Secondary Glioblastoma
Hiroko Ohgaki,Paul Kleihues +1 more
TL;DR: IDH1 mutations are the earliest detectable genetic alteration in precursor low-grade diffuse astrocytomas and in oligodendrogliomas, indicating that these tumors are derived from neural precursor cells that differ from those of primary glioblastomas.
Journal ArticleDOI
Pharmaco-metabonomic phenotyping and personalized drug treatment.
T. Andrew Clayton,John C. Lindon,Olivier Cloarec,Henrik Antti,Claude Charuel,Gilles Hanton,Jean-Pierre Provost,Jean-Loic Le Net,David Baker,Rosalind Walley,Jeremy R. Everett,Jeremy K. Nicholson +11 more
TL;DR: An alternative and conceptually new ‘pharmaco-metabonomic’ approach to personalizing drug treatment is described, which uses a combination of pre-dose metabolite profiling and chemometrics to model and predict the responses of individual subjects.
Journal ArticleDOI
IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas
TL;DR: IDH1 mutations are a strong predictor of a more favorable prognosis and a highly selective molecular marker of secondary glioblastomas that complements clinical criteria for distinguishing them from primary gliOBlastomas.
Journal Article
FK866, a Highly Specific Noncompetitive Inhibitor of Nicotinamide Phosphoribosyltransferase, Represents a Novel Mechanism for Induction of Tumor Cell Apoptosis
Max Hasmann,Isabel Schemainda +1 more
TL;DR: This work has identified the first low molecular weight compound, designated FK866, which induces apoptosis by highly specific, noncompetitive inhibition of nicotinamide phosphoribosyltransferase (NAPRT), a key enzyme in the regulation of NAD+ biosynthesis from the natural precursor Nicotinamide.
Journal ArticleDOI
Genetic alterations and signaling pathways in the evolution of gliomas
Hiroko Ohgaki,Paul Kleihues +1 more
TL;DR: The current status of genetic alterations and signaling pathways operative in the evolution of astrocytic and oligodendroglial tumors is summarized.