TFOS DEWS II pathophysiology report
Citations
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1,821 citations
1,758 citations
Cites background or methods from "TFOS DEWS II pathophysiology report..."
...Further etiological breakdown is described in detail in the Pathophysiology report [1]....
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...This dry eye classification scheme incorporates triaging elements to provide clarity in diagnosing DED (via the Diagnostic Methodology report) [15], fromwhich the various etiologies can be considered (see Pathophysiology report) [1] and an appropriate management plan can be instituted (see Management and Therapy report) [16]....
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...The revised classification system directs the reader, in considering potential contributing etiologic elements, toward the TFOS DEWS II Pathophysiology report, where these elements are described in more detail [1]....
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...A number of critical points were discussed, including acknowledgement that a loss of tear film homeostasis can arise from a multitude of factors that encompass eyelid and blink abnormalities, in addition to ocular surface or tear component deficiencies [1,5]....
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...When applied to DED, the concept of disrupted tear film homeostasis acknowledges the possibility of the many different changes that can occur in the tear film and ocular surface [5], in response to one or more of the underlying causes of dry eye [1]....
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1,152 citations
785 citations
Cites background from "TFOS DEWS II pathophysiology report..."
...Common causes of postoperative dry eye include chemosis, increased exposure of the ocular surface, lagophthalmos, lower eyelid malposition, or diminished blink reflex from surgical anesthesia or oedema [102,483]....
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...Further details on the impact of abnormal blink patterns and eye closure on DED are detailed in the TFOS DEWS II Pathophysiology Report [483]....
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582 citations
References
8,642 citations
"TFOS DEWS II pathophysiology report..." refers background in this paper
...During EMT, epithelial cells lose cell-cell and cell-matrix attachments, polarity and epithelialspecific markers, undergo cytoskeletal remodeling, and gain a mesenchymal phenotype [33]....
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...A key mechanism in the murine gland is epithelial-mesenchymal transition (EMT), which, during embryogenesis, helps epithelial cells to acquire migratory and/or invasive properties [33]....
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8,052 citations
"TFOS DEWS II pathophysiology report..." refers background in this paper
...Induction of EMT generates cells with mesenchymal stem-like properties, which can play a significant role in tissue repair [34,35]....
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