TGF-β2 dictates disseminated tumour cell fate in target organs through TGF-β-RIII and p38α/β signalling
Paloma Bragado,Yeriel Estrada,Falguni Parikh,S Krause,Carla S. Capobianco,Hernan G. Farina,Denis M. Schewe,Julio A. Aguirre-Ghiso +7 more
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TLDR
A ‘seed and soil’ mechanism where TGF-β2 and T GF-β-RIII signalling through p38α/β regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis is revealed.Abstract:
Aguirre-Ghiso and colleagues report that the intensity of TGF-β2 signalling dictates dormancy or metastatic growth of disseminated tumour cells by regulating the activity of p38α/β in different target organs.read more
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Emerging Biological Principles of Metastasis
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References
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The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited
TL;DR: It is now known that the potential of a tumour cell to metastasize depends on its interactions with the homeostatic factors that promote tumour-cell growth, survival, angiogenesis, invasion and metastasis.
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In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells
Gabriela Dontu,Wissam M. Abdallah,Jessica M. Foley,Kyle W. Jackson,Michael F. Clarke,Mari J. Kawamura,Max S. Wicha +6 more
TL;DR: It is demonstrated that nonadherent mammospheres are enriched in early progenitor/stem cells and able to differentiate along all three mammary epithelial lineages and to clonally generate complex functional structures in reconstituted 3D culture systems.
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Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer.
Peter M. Siegel,Joan Massagué +1 more
TL;DR: The cytostatic and apoptotic functions of transforming growth factor-β (TGF-β) help restrain the growth of mammalian tissues; loss of these effects leads to hyperproliferative disorders and is common in cancer.
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Models, mechanisms and clinical evidence for cancer dormancy.
TL;DR: Experimental and clinical evidence is reviewed that supports the existence of various mechanisms of cancer dormancy including angiogenic dormancy, cellular dormancy (G0–G1 arrest) and immunosurveillance.
Journal Article
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor.
TL;DR: A panel of 5 subpopulations is evaluated that identifies different points of selective failure in tumor cell dissemination and should be valuable in the assessment of antimetastatic therapies.