Th9 cells: differentiation and disease.
Citations
374 citations
Cites background from "Th9 cells: differentiation and dise..."
...1/Smad/Stat6 for Th9, RORγt/Stat3 for Th17, and Foxp3/Stat5 for iTreg [148, 149]....
[...]
...In the presence of IL-4 and TGF-β, naïve CD4 T cells may differentiate into Th9 cells secreting IL-9, IL-10, and IL-21, which regulate allergic inflammation, autoimmune inflammation, and antitumor immunity [149]....
[...]
346 citations
Cites background from "Th9 cells: differentiation and dise..."
...A new subset of T helper cells, Th9, produces IL-9 found in the peripheral blood of allergic patients [114]....
[...]
317 citations
299 citations
297 citations
References
2,915 citations
2,356 citations
1,825 citations
1,458 citations
1,164 citations
"Th9 cells: differentiation and dise..." refers background in this paper
...IL4, its receptor, STAT6, and GATA3 are required for both Th2 and Th9 cell development (2, 4, 10)....
[...]
...Not surprisingly, considering the importance of IL-4 in the development of Th9 cells, STAT6 is absolutely required for IL-9 production (2, 4, 10)....
[...]
...Initial reports utilized mice expressing a dominant negative TGFbRII transgene in CD4 T cells to demonstrate that Th9 cells are required for immunity to Trichuris muris (4)....
[...]
...TGFb can convert Th2 cells to IL-9secreting cells (4)....
[...]