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Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul (Anura: Leptodactylidae: Leiuperinae) with activity against Escherichia coli.

Mariela M. Marani, +21 more
- 20 Mar 2017 - 
- Vol. 605, pp 70-80
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TLDR
Patagonia's biodiversity has been explored from many points of view, however, skin secretions of native amphibians have not been evaluated for antimicrobial peptide research until now and the first peptides described for amphibians of the Pleurodema genus are described.
About: 
This article is published in Gene.The article was published on 2017-03-20 and is currently open access. It has received 21 citations till now. The article focuses on the topics: Antimicrobial peptides & Pleurodema.

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Exploring Molecular-Biomembrane Interactions with Surface Plasmon Resonance and Dual Polarization Interferometry Technology: Expanding the Spotlight onto Biomembrane Structure

Tzong-Hsien Lee, +4 more
- 25 May 2018 - 
TL;DR: A review of the application of surface plasmon resonance and dual polarization interferometry-based biosensors to the study of biomembrane-based systems using both planar mono- or bilayers or liposomes is presented.
Journal ArticleDOI

Synergistic and antibiofilm properties of ocellatin peptides against multidrug-resistant Pseudomonas aeruginosa.

Lucinda J. Bessa, +10 more
- 08 Jan 2018 - 
TL;DR: Ocellatin-PT3 may be promising as a template for the development of novel antimicrobial peptides against P. aeruginosa, and was capable of preventing the proliferation of 48-h mature biofilms at concentrations ranging from 4 to 8× the MIC.
Journal ArticleDOI

Biological properties of chitosan derivatives associated with the ceftazidime drug.

L. A. Pereira, +5 more
- 15 Oct 2019 - 
TL;DR: The biocompatibility of the derivatives was confirmed by the low hemolytic rate (<5%), non-toxic on Artemia salina (LD50%>3000 ppm), and significant index (1-34%) of antioxidant activity, and the results demonstrated that chitosan and its derivatives are promising biomaterials.
Journal ArticleDOI

An Atlas of Anionic Antimicrobial Peptides from Amphibians.

Sarah R. Dennison, +3 more
- 25 Dec 2018 - 
TL;DR: It is concluded that amphibian AAMPs represent an untapped potential source of biologically active agents and merit far greater research interest.
Journal ArticleDOI

Bioinspired Designs, Molecular Premise and Tools for Evaluating the Ecological Importance of Antimicrobial Peptides

Elvis Legala Ongey, +2 more
- 10 Jul 2018 - 
TL;DR: An overview of recent developments in antimicrobial peptides (AMPs), summarizing structural diversity, potential new applications, activity targets and microbial killing responses in general is provided.
References
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Journal ArticleDOI

Discovery and applications of the plant cyclotides

David J. Craik
- 15 Dec 2010 - 
TL;DR: The cyclotides are the largest of several groups of naturally occurring circular proteins that have been discovered in bacteria, plants and animals over recent years and their applications in drug design are described.
Journal ArticleDOI

Secretory leukocyte protease inhibitor binding to mRNA and DNA as a possible cause of toxicity to Escherichia coli.

K W Miller, +3 more
- 01 Apr 1989 - 
TL;DR: The results indicate that high-level expression of basic recombinant proteins in E. coli may be problematic, and it is concluded that SLPI binds to nucleic acids via charge interactions and inhibits translation by competing with ribosomes for binding to mRNA.
Journal Article

Mode of action of anticancer peptides (ACPs) from amphibian origin.

Christopher Oelkrug, +2 more
- 01 Feb 2015 - 
TL;DR: Novel anticancer agents are supposed not to cause serious side effects and the formation of multidrug-resistant tumor cells and promising candidates were isolated from skin secretions of amphibians, such as the granular glands of the Chinese brown frog, Rana chensinensis.
Journal ArticleDOI

Insulin-releasing properties of the frog skin peptide pseudin-2 and its [Lys18]-substituted analogue.

Yasser Abdel-Wahab, +4 more
- 01 Feb 2008 - 
TL;DR: The results demonstrate that pseudin-2 stimulates insulin secretion from BRIN-BD11 cells by a mechanism involving Ca2+-independent pathways and identify [Lys18]-pseudin- 2 as a peptide that may have potential for development as a therapeutically valuable insulinotropic agent for the treatment of type 2 diabetes.
Journal ArticleDOI

Liquid storage of boar semen: Current and future perspectives on the use of cationic antimicrobial peptides to replace antibiotics in semen extenders.

Martin Schulze, +3 more
- 01 Jan 2016 - 
TL;DR: Bacterial selectivity, proteolytic stability, thermodynamic resistance, and potential synergistic interaction with conventional antibiotics propel predominantly cyclic hexapeptides into highly promising, leading candidates for further development in semen preservation.
Related Papers (5)

Characterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus.

Mariela M. Marani, +15 more
- 24 Jun 2015 - 

The NMR-derived solution structure of a new cationic antimicrobial peptide from the skin secretion of the anuran Hyla punctata.

Maura V. Prates, +10 more
- 26 Mar 2004 - 

Antimicrobial peptides isolated from skin secretions of the diploid frog, Xenopus tropicalis (Pipidae).

Mohamed F. Ali, +3 more
- 26 Nov 2001 - 

Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta.

Cesar Vicente Ferreira Batista, +9 more
- 01 Aug 1999 - 

Length Effects in Antimicrobial Peptides of the (RW)n Series

Zhigang Liu, +6 more
- 01 Feb 2007 - 
Frequently Asked Questions (2)
Q1. What contributions have the authors mentioned in the paper "Thaulin-1: the first antimicrobial peptide isolated from the skin of a patagonian frog pleurodema thaul (anura: leptodactylidae: leiuperinae) with activity against escherichia coli" ?

Please cite this article as: Mariela M. Marani, Luis O. Perez, Alyne Rodrigues de Araujo, Alexandra Plácido, Carla F. Sousa, Patrick Veras Quelemes, Mayara Oliveira, Ana G. Gomes-Alves, Mariana Pueta, Paula Gameiro, Ana M. Tomás, Cristina Delerue-Matos, Peter Eaton, Silvia A. Camperi, Néstor G. Basso, Jose Roberto de Souza de Almeida Leite, Thaulin-1: The first antimicrobial peptide isolated from the skin of a Patagonian frog Pleurodema thaul ( Anura: Leptodactylidae: Leiuperinae ) with activity against Escherichia coli. The address for the corresponding author was captured as affiliation for all authors. 

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